Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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affected by a growing number of DNA alterations in tumor-suppressor genes, especially via gene promoter methylation ( 4 ) causing a silencing of tumor-suppressor genes that are linked to apoptosis or DNA repair ( 5 , 6 ). A better understanding of such
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methylation ( 8 ). Additionally, methylation of HpaII and HhaI sites near the polymorphic CAG repeats was reported in the human AR gene ( 9 ). Research has revealed that the development of CRCs is due to multistep processes as a consequence of the
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany
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Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive and Endocrine Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive and Endocrine Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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mutations, chromosome alteration and DNA methylation profile, or at the RNA level, including transcriptome and targeted gene expression profiles. Intratumor heterogeneity of somatic mutations has been reported in many cancer types ( 12 , 13 , 14 ). In a
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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carry epigenetic changes that persist for many years and predispose them to developing complications ( 9 , 11 , 12 , 13 ). Several studies in patients with T2DM have found changes in the genome methylation profile, such as a reduced level of DNA
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University Hospital, Krakow, Poland
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University Hospital, Krakow, Poland
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University Hospital, Krakow, Poland
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University Hospital, Krakow, Poland
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standard therapy ( 9 ). In light of this prior evidence of differential expression of several genes between the two treatment methods ( 9 ), it seemed strongly justified to test whether these can also be seen at the epigenetic level of gene methylation, a
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Introduction N6-methyladenosine (m6A) is one of the most prevalent and abundant methylations in mRNA and viral RNA. The dysregulation of RNA modification has been linked to obesity, diabetes, metabolic syndrome, cancer, and other human
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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associated with inflammation and depression ( 29 , 30 ), features that, as mentioned earlier, have been also observed in PFS model ( 28 ). In this setting, the evaluation of the methylation pattern remains challenging since it could change during adulthood
Department of Endocrinology, The People’s Hospital of Daxing District, Beijing, China
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methylation (DNAm) patterns associated with GO ( 3 , 4 ). BOLL , MBP , and CDK5 are potential genes associated with GO, according to the genome-scale screening of DNAm and the single methylation sequencing validation using enlarged samples ( 5 ). These
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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epigenetic studies. We have previously published one of the first studies demonstrating changes in DNA methylation patterns with the onset of puberty in healthy children ( 12 ) and identified the promotor of the thyroid hormone receptor interactor 6 gene
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chromatin that influence gene expression ( 23 ). The methylation of cytosine paired with a guanine (CpG) termed ‘DNA methylation’ is one of the many epigenetic mechanisms that govern gene expression where approximately 70–80% of CpG dinucleotides are