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cortisol ( 7 , 8 , 9 ). Furthermore, in childhood obesity, indices of cortisol production were positively associated with components of the metabolic syndrome, that is, a cluster of metabolic abnormalities characterized by abdominal fat distribution
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long-term consequences, such as to increase the risk of metabolic syndrome ( 11 , 12 ) and secondary osteoporosis ( 13 ). Adolescents affected by pubertal delay often feel distressed by their condition. This may have an important impact on quality of
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growth . The few data on head circumference before 36 weeks suggest asymmetric growth restriction in some of these neonates, which may have long term implications such as increased risk for metabolic syndrome and noncommunicable diseases later in life