Department of Pediatric Cardiology, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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transcription factors, splicing factors, or RNA-decay machinery ( 17 , 18 ). In this study, we aimed to identify lncRNA–mRNA pairs that play a functional role in GD. We found that patients with newly diagnosed GD had significantly higher numbers of B cells
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, and aggressiveness e.g., non-progressive vs malignant/metastatic) ( 41 , 42 ) and have demonstrable predictive utility at a tissue level ( 43 ). More recently, blood-based assays (CTCs, miRNA and circulating mRNA) have been developed. The most
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expression of VDR mRNA in malignant thyroid tissues is higher than that in normal thyroid ( 2 ). They also reported correlations between VDR and other genes such as ECM1 (extracellular matrix protein-1) and TMPRSS4 (type II transmembrane serine
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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GD remains limited. In this study, an lncRNA and mRNA expression profile for GD CD4+ T cells were established, and the relationships between the expression levels of aberrantly expressed lncRNAs and clinical indices were analyzed. Materials and
Imperial College London, London, UK
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to the AR mRNA transcript and may be in part responsible for increased AR mRNA and protein expression in response to AR-antagonist-mediated hormone starvation. Materials and methods Cell culture LNCaP cells were maintained at 37°C, 5% CO
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. Unlike most cells whose mRNA transcripts lasts for only a few hours ( 50 ), an oocyte transcribes mRNAs to last several days ( 50 ) from fertilization to blastulation and implantation ( 50 ). The longevity of these mRNA transcripts in this unique
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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thyroid cancer and HOPXβ mRNA expression. Pt. (M/F) Age (years) Histology MF EE Invasion LN TNM staging Risk HOPXβ mRNA (AU) Capsular Vascular Perineural Metastasis T N M ATA AJCC Nontumor Tumor
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was adopted for the analysis of microarray data and the identification of statistical specifications for significance. The differential expression of lncRNA and mRNA was screened for greater changes. A P -value of ≤ 0.05 was considered statistically
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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-renal adipose tissue 23 ♀/29 ♂ 23 ♀/24 ♂ Lipids in plasma 24 ♀/30 ♂ 24 ♀/24 ♂ ZT, zeitgeber time; CT, circadian time. n , number of mice included from start. Tissue mRNA extraction Approximately 30–50 mg fat tissue was
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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starvation regulates D3 mRNA expression and activity in liver and white adipose tissue, the mechanisms involved are incompletely understood. To this end, we studied the effect of a variety of molecular determinants involved in nutrient sensing (including the