Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
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Introduction Hypothyroidism is a common endocrine disease, affecting about 3% of the general population ( 1 ), with levothyroxine substitution therapy being the standard treatment ( 2 , 3 ). Hypothyroidism is associated with increased body
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recommend measuring TSH in women with TAB at the time of confirmation of pregnancy and monthly during mid-pregnancy ( 8 ). Effects of levothyroxine during pregnancy A large database study of 1013 pregnancies in the UK, where LT4 was started at least
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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samples with fT4 > ULN and a slightly suppressed TSH and 72% of the samples with fT4 > ULN and a TSH within the reference interval belonged to levothyroxine (L-T4) users, as shown in Fig. 1 . Furthermore, we noticed that, respectively, 4.7 and 8.2% of the
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hypothyroidism. Therefore, thyroxine/free thyroxine (T4/fT4) levels are used as an additional parameter for therapy adjustment in patients treated with levothyroxine (LT4). However, peripheral euthyroidism cannot be reliably assessed even with both parameters
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(GDM), and placental abruption ( 1 , 2 , 3 ). A previous study ( 4 ) about thyroid disease and pregnancy outcomes showed that SCH increased the odds of adverse pregnancy outcomes and that levothyroxine (LT4) administration improved pregnancy outcomes
Diabetes and Endocrine Unit, National Hospital, Kandy, Sri Lanka
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Introduction Refractory hypothyroidism is characterized by an inadequate response to the standard dose of levothyroxine, resulting in persistent biochemical or clinical hypothyroidism ( 1 ). The recommended average daily dose of levothyroxine
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Introduction Oral levothyroxine (LT4) is the mainstay therapy for hypothyroidism. Absorption of oral LT4 occurs primarily in the small intestine within the first 3 h of ingestion, with an absorption rate of 60–80% ( 1 ). Initial LT4 dosing is
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exhibited elevated serum TSH levels but maintained normal thyroid hormone levels compared to control mouse. To normalize TSH levels, mice with subclinical hypothyroidism were provided with levothyroxine in their drinking water for 2 weeks. Levothyroxine (5
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, including fatigue or tiredness, of levothyroxine-treated patients were significantly related to a low concentration of fT3 ( 17 ). The objectives of the present study were to determine the prevalence of fatigue among postoperative patients with PTC and to
Department of Hematology, University of Groningen, University Medical Center Groningen, The Netherlands
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Introduction Hypothyroidism is a common endocrine disorder. Treatment with levothyroxine has been considered the standard of care for patients with established primary hypothyroidism, and its use has been enforced in all international