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Josephina G Kuiper
Josephina G Kuiper
PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
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Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
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Aline C Fenneman
Aline C Fenneman
Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Anne H van der Spek
Anne H van der Spek
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Elena Rampanelli
Elena Rampanelli
Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Max Nieuwdorp
Max Nieuwdorp
Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Myrthe P P van Herk-Sukel
Myrthe P P van Herk-Sukel
Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands
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Valery E P P Lemmens
Valery E P P Lemmens
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands
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Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands
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Ernst J Kuipers
Ernst J Kuipers
Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands
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Ron M C Herings
Ron M C Herings
PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands
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Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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.nivel.nl/nl/nivel-zorgregistraties-eerste-lijn/jaarcijfers-aandoeningen-incidenties-en-prevalenties ). Treatment of primary hypothyroidism consists of hormone substitution therapy with daily oral administration of the synthetic thyroid hormone levothyroxine. The majority of levothyroxine is absorbed in the upper gastrointestinal tract, ranging from 40 to 80
Xiaoya Zheng
Xiaoya Zheng
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shanshan Yu
Shanshan Yu
Pathology Department, Chongqing Medical University, Chongqing, China
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Jian Long
Jian Long
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qiang Wei
Qiang Wei
Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China
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Liping Liu
Liping Liu
Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chun Liu
Chun Liu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wei Ren
Wei Ren
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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having an elevated TSH value >5.91 µIU/mL or being on levothyroxine replacement therapy at the time of diagnosis. The diagnosis of HT was suggested by a typical ultrasound pattern or by the presence of antithyroid antibodies ( 17 ). Statistical
Hanna Karhapää
Hanna Karhapää
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Siru Mäkelä
Siru Mäkelä
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Hanna Laurén
Hanna Laurén
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Marjut Jaakkola
Marjut Jaakkola
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Camilla Schalin-Jäntti
Camilla Schalin-Jäntti
Medical Faculty, University of Helsinki, Helsinki, Finland
Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Micaela Hernberg
Micaela Hernberg
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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patients (12%) had a borderline level of TSHRAbs, and 7 patients (5%) had elevated TPOAbs. Prior to ICI treatment, 19 patients (14%) had primary hypothyroidism and were on levothyroxine treatment. None of the patients with a previous diagnosis of
Ruth Percik
Ruth Percik
Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel
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Sherwin Criseno
Sherwin Criseno
Department of Endocrinology, University Hospital Birmingham, Birmingham, UK
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Safwaan Adam
Safwaan Adam
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK
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Kate Young
Kate Young
Royal Marsden Hospital, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK
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Royal Marsden Hospital, London, UK
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) ( Fig. 2 ). Replacement with levothyroxine and sex hormones may be required as per standard approaches in time, although morning cortisol should always be checked and replacement initiated prior to starting levothyroxine. Whilst there is some evidence of
