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(adiponectin, IL-10) ( 4 ). Chronic inflammation in obese adipose tissues is characterized by a substantial infiltration of macrophages ( 5 ). In the context of prolonged positive energy homeostasis, adipose tissue undergoes expansion to accommodate increased
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-mediated inflammation and pyroptosis Immunofluorescence staining and semiquantitative analysis showed that the expression of NLRP3 and IL-1β proteins in the kidneys of mice in the DN and DN + RI groups was significantly increased compared with that in the
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group) and PAI-1 (T2D group). Discussion We examined the impact of body mass and T2D on average daily concentrations and the diurnal rhythms of plasma glucose, TAG and ten hormones related to glucose regulation and inflammation under controlled
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of immature myeloid cells with potent immunosuppressive activity. During pathological processes such as cancer, chronic inflammation, and trauma, myeloid cells undergo a conversion to MDSCs, which exert immunosuppressive effects on T cells ( 3
Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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, diabetes may aggravate the development and prognosis of COPD by affecting lung physiology, inflammation, and susceptibility to bacterial infection directly ( 4 ). The presence of diabetes among those with COPD is associated with worse outcomes including
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included WC, BMI, and systemic immune-inflammation index (SII, calculated as the product of peripheral platelet count and neutrophil-to-lymphocyte ratio) ( 24 , 25 ). Questionnaire variables composed of alcohol use, diabetes, minutes sedentary activity
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inflammation and chronic ischemia can induce SDF-1 production in systemic tissues through hypoxia-inducible factor 1 (HIF-1) ( 12 ). It has been confirmed that elevated SDF-1 levels can promote the onset and progression of T2D by inducing islet inflammation
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apoptosis), autophagy, bone remodeling, atherosclerosis, tumor metastasis, as well as roles in inflammation and cerebral amyloid angiopathy ( 10 , 11 ). Actually, CysC is a disease-associated protein, and alteration in CysC levels may suggest important
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systemic inflammation. NAFLD is associated with a series of complex events. The ‘double-hit’ theory used to be a widely accepted explanation for the etiology of NAFLD ( 27 ). However, mounting evidence has suggested that the pathophysiology of NAFLD is
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develop type 2 diabetes mellitus 10 years after GDM ( 2 , 3 , 4 , 5 ). Women with GDM typically have different levels of insulin resistance and possible chronic low-grade inflammation, which trigger vascular injury and dysfunction and subsequent