Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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proinflammatory mediators in order to remove the damaging agent and restoring tissue function and structure (1) . Biologically, inflammation advances through several stages. At the cellular level there is a marked response to proinflammatory stimuli, and as a
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Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
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and metabolic disturbances that cause hypertension, insulin resistance and dyslipidemia in acromegaly patients ( 6 ). Interestingly, CVD is strongly associated with subclinical systemic inflammation ( 9 , 10 ). Vascular wall inflammation is an
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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GLP-1 exhibits cardio- and neuro-protection, together with inhibition of inflammation and apoptosis ( 6 ). An excessive inflammatory response can cause severe organ dysfunction ( 7 ). Increased blood glucose levels are frequently observed in septic
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Medical Research Laboratories, Departments of Clinical Biochemistry, Molecular Medicine, Department of Clinical Genetics, Department of Endocrinology and Internal Medicine, Clinical Institute, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark
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have been linked to states of low-grade inflammation such as diabetes, obesity, liver disease, and atherosclerosis (5, 6, 7, 8, 9, 10, 11) , underscoring the important role of macrophages in initiating and propagating these conditions. Previously, we
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). Obesity is a central risk factor for developing NAFLD ( 4 ), and it is estimated that 39% of all adults worldwide are overweight and 13% are obese ( 5 ). NASH is a further deterioration from the steatosis characteristic of NAFLD accompanied by inflammation
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. Astragaloside IV (AS-IV) is one of the most effective components of stragalus membranaceus , and AS-IV is reported to have a wide range of pharmacological properties, including anti-inflammation, anti-oxidant and anti-hypertension, as well as improving immunity
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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toxicity of lipopolysaccharide (LPS) and sepsis (28) . FGF21 can also reduce the severity of cerulein-induced pancreatitis in mice (29) , further indicating that FGF21 could modulate inflammation. These findings highlight the possible role of FGF21 as a
School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
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challenge, the sustained presence of these cells may lead to unregulated inflammation. It has therefore been proposed that a key immune function of 1,25D is to moderate the magnitude of inflammatory adaptive immune responses, thereby limiting potentially
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). Inflammation and oxidative stress are two common targets for therapies against GDM. Placental inflammation and GDM have been closely correlated, and both of them play essential roles in shaping the fetal environment ( 14 ). Inflammation is highly regulated in
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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that adipose tissue fibrosis is strongly associated with inflammation. Adipose tissue inflammation causes insulin resistance, which in turn promotes inflammation ( 10 ). Adipose tissue mRNA levels of pro-fibrotic genes were positively correlated with