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Introduction The immune checkpoint inhibitors (ICIs) are a group of relatively new biological agents that have revolutionised therapy for a group of cancers, including melanoma, renal and some lung tumours. A side effect of these treatments is
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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by Patti et al. in 2020 revealed a new avenue of research relating RT, endocrinology, and the immune system in individuals with childhood-onset brain tumours. They investigated the presence of anti-pituitary and anti-hypothalamus autoantibodies in
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radiotherapy ( 1 ). Data supporting an association between GH deficiency and conventional, including intrathecal, chemotherapy are limited ( 8 , 13 ). In more recent years, tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors have been identified
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Department of Clinical Research, University of Basel, Basel, Switzerland
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University Center of Cardiovascular Science & Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg–Kiel–Lübeck, Hamburg, Germany
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-releasing hormone-independent stimulator of the adrenal axis during immune system activation . PNAS 2000 97 9317 – 9322 . ( https://doi.org/10.1073/pnas.97.16.9317 ) 27 Mastorakos G Weber JS Magiakou MA Gunn H Chrousos GP . Hypothalamic
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function, like immune and visual function, seems to depend more on extrapituitary circuits, namely insulin ( 4 , 5 ), IGF2 ( 6 ), brain GH ( 7 ), and brain IGF1 and IGF2 ( 8 , 9 ) than on the classical somatotropic axis (pituitary GH and circulating IGF1
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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. ( https://doi.org/10.1038/onc.2008.414 ) 14 Ruiu R Cossu C Iacoviello A Conti L Bolli E Ponzone L Magri J Rumandla A Calautti E & Cavallo F . Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune
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patient received thyroxine for treatment of auto-immune hypothyroidism and one patient received atenolol for high blood pressure treatment. All other patients received no medication. The brain images were evaluated for major pathologies (e.g. stroke, tumor
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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cancer survivors . Pediatric Clinics of North America 2020 67 1171 – 1186 . ( https://doi.org/10.1016/j.pcl.2020.08.002 ) 11 Plant-Fox AS O'Halloran K & Goldman S . Pediatric brain tumors: the era of molecular diagnostics, targeted and immune
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National Center for Children’s Health, Beijing, China
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clinical factors related to antibody-mediated immune response to the subfornical organ . Clinical Endocrinology 2022 97 72 – 80 . ( https://doi.org/10.1111/cen.14737 ) 16 Udrea DS Lopez M Avesar M Qureshi S Moretti A Abd-Allah SA
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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brain injury: opportunities for therapeutic intervention . Brain, Behavior, and Immunity 2012 26 1191 – 1201 . ( https://doi.org/10.1016/j.bbi.2012.06.008 ) 18 Tanriverdi F De Bellis A Battaglia M Bellastella G Bizzarro A Sinisi AA