Search Results
Search for other papers by Zhenyu Liu in
Google Scholar
PubMed
Search for other papers by Huixi Kong in
Google Scholar
PubMed
Search for other papers by Baoyu Zhang in
Google Scholar
PubMed
To optimize the treatment plan for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia, this narrative literature review summarizes the effect of antidiabetic drugs on serum uric acid (SUA) levels using data from observational studies, prospective clinical trials, post hoc analyses, and meta-analyses. SUA is an independent risk factor for T2DM, and evidence has shown that patients with both gout and T2DM exhibit a mutually interdependent effect on higher incidences. We find that insulin and dipeptidyl peptidase 4 inhibitor (DPP-4i) except linagliptin could increase the SUA and other drugs including metformin, thiazolidinediones (TZDs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), linagliptin, sodium–glucose cotransporter 2 inhibitors (SGLT2i), and α-glucosidase inhibitors have a reduction effect on SUA. We explain the mechanisms of different antidiabetic drugs above on SUA and analyze them compared with actual data. For sulfonylureas, meglitinides, and amylin analogs, the underlying mechanism remains unclear. We think the usage of linagliptin and SGLT2i is the most potentially effective treatment of patients with T2DM and hyperuricemia currently. Our review is a comprehensive summary of the effects of antidiabetic drugs on SUA, which includes actual data, the mechanisms of SUA regulation, and the usage rate of drugs.
Search for other papers by Zhaoxiang Liu in
Google Scholar
PubMed
Search for other papers by Mingqiang Zhang in
Google Scholar
PubMed
Search for other papers by Xiaohu Shi in
Google Scholar
PubMed
Search for other papers by Wenhui Zhao in
Google Scholar
PubMed
Search for other papers by Chenxiang Cao in
Google Scholar
PubMed
Search for other papers by Lixia Jin in
Google Scholar
PubMed
Search for other papers by Yanlei Wang in
Google Scholar
PubMed
Search for other papers by Jianzhong Xiao in
Google Scholar
PubMed
-grade inflammatory disease characterized by increased circulating concentrations of inflammatory cytokines and the recruitment of immune cells, including macrophages and T cells, to metabolic tissues ( 2 ). Myeloid-derived suppressor cells (MDSCs) represent a group
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Weiwei He in
Google Scholar
PubMed
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Caoxin Huang in
Google Scholar
PubMed
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Search for other papers by Xiulin Shi in
Google Scholar
PubMed
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Menghua Wu in
Google Scholar
PubMed
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Han Li in
Google Scholar
PubMed
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Qiuhong Liu in
Google Scholar
PubMed
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Xiaofang Zhang in
Google Scholar
PubMed
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Search for other papers by Yan Zhao in
Google Scholar
PubMed
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China
Search for other papers by Xuejun Li in
Google Scholar
PubMed
assembly, and extracellular structural organization ( Fig. 8D ). Functional annotation analysis of MEgreenyellow and MEturquoise co-expression modules showed that their functions were both characterized by immune response-related pathways (Supplementary Fig
Search for other papers by Huiyuan Zhai in
Google Scholar
PubMed
Search for other papers by Dongxu Wang in
Google Scholar
PubMed
Search for other papers by Yong Wang in
Google Scholar
PubMed
Search for other papers by Hongwei Gu in
Google Scholar
PubMed
Search for other papers by Juan Jv in
Google Scholar
PubMed
Search for other papers by Liangliang Yuan in
Google Scholar
PubMed
Search for other papers by Chao Wang in
Google Scholar
PubMed
Search for other papers by Leiyao Chen in
Google Scholar
PubMed
as a signaling molecule in immunity and inflammation, activated by various stress signals, including viral infections. Upon cytoplasmic DNA binding, cyclic GMP-AMP synthase (cGAS) facilitates the generation of cyclic guanosine monophosphate
Surgery Research Unit, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Search for other papers by Olli Helminen in
Google Scholar
PubMed
Search for other papers by Tytti Pokka in
Google Scholar
PubMed
Search for other papers by Susanna Aspholm in
Google Scholar
PubMed
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
Search for other papers by Jorma Ilonen in
Google Scholar
PubMed
Search for other papers by Olli G Simell in
Google Scholar
PubMed
Pediatric Research Center, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Search for other papers by Mikael Knip in
Google Scholar
PubMed
Search for other papers by Riitta Veijola in
Google Scholar
PubMed
small ( 31 ). It should be accepted that in the evolution of type 1 diabetes, as in other autoimmune diseases, multiple immune pathways are involved. It seems that any treatment aimed at changing the disease course needs to be performed with agents
Search for other papers by Sun Fei in
Google Scholar
PubMed
Search for other papers by Min Liu in
Google Scholar
PubMed
Search for other papers by Hu Shanshan in
Google Scholar
PubMed
Search for other papers by Ruijie Xie in
Google Scholar
PubMed
Search for other papers by Wu Danni in
Google Scholar
PubMed
Search for other papers by Zhou Ningying in
Google Scholar
PubMed
included WC, BMI, and systemic immune-inflammation index (SII, calculated as the product of peripheral platelet count and neutrophil-to-lymphocyte ratio) ( 24 , 25 ). Questionnaire variables composed of alcohol use, diabetes, minutes sedentary activity
Search for other papers by Felix Reschke in
Google Scholar
PubMed
Search for other papers by Torben Biester in
Google Scholar
PubMed
Search for other papers by Thekla von dem Berge in
Google Scholar
PubMed
Search for other papers by Dagmar Jamiolkowski in
Google Scholar
PubMed
Search for other papers by Laura Hasse in
Google Scholar
PubMed
Search for other papers by Francesca Dassie in
Google Scholar
PubMed
Search for other papers by Pietro Maffei in
Google Scholar
PubMed
Search for other papers by Katharina Klee in
Google Scholar
PubMed
Search for other papers by Olga Kordonouri in
Google Scholar
PubMed
Search for other papers by Hagen Ott in
Google Scholar
PubMed
Search for other papers by Thomas Danne in
Google Scholar
PubMed
response to oral antidiabetics: Bullous pemphigoid (BP) is an acquired subepidermal autoimmune vesicular blistering disease with cellular humoral immune response to BP-180 and BP-230 antigens. BP can be triggered by several drugs. Several reports revealed
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
Search for other papers by Fabyan Esberard de Lima Beltrão in
Google Scholar
PubMed
Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Search for other papers by Daniele Carvalhal de Almeida Beltrão in
Google Scholar
PubMed
Search for other papers by Giulia Carvalhal in
Google Scholar
PubMed
Search for other papers by Fabyo Napoleão de Lima Beltrão in
Google Scholar
PubMed
Search for other papers by Igor Motta de Aquino in
Google Scholar
PubMed
Search for other papers by Thaíse da Silva Brito in
Google Scholar
PubMed
Search for other papers by Barbara Costa Paulino in
Google Scholar
PubMed
Search for other papers by Elisa Aires in
Google Scholar
PubMed
Search for other papers by Diana Viegas in
Google Scholar
PubMed
Search for other papers by Fabio Hecht in
Google Scholar
PubMed
Search for other papers by Bruno Halpern in
Google Scholar
PubMed
Search for other papers by Liana Clebia De Morais Pordeus in
Google Scholar
PubMed
Search for other papers by Maria da Conceição Rodrigues Gonçalves in
Google Scholar
PubMed
Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
Search for other papers by Helton Estrela Ramos in
Google Scholar
PubMed
, angiogenesis, hematopoiesis, osteogenesis, reproduction, and immune function ( 19 , 20 ). Nonetheless, in obesity, leptin is almost universally high, and obesity is considered a state of leptin resistance. Zhang and coworkers studied the pathogenesis of 2009
Search for other papers by Yang Yu in
Google Scholar
PubMed
Search for other papers by Hairong Hao in
Google Scholar
PubMed
Search for other papers by Linghui Kong in
Google Scholar
PubMed
Search for other papers by Jie Zhang in
Google Scholar
PubMed
Search for other papers by Feng Bai in
Google Scholar
PubMed
Search for other papers by Fei Guo in
Google Scholar
PubMed
Search for other papers by Pan Wei in
Google Scholar
PubMed
Search for other papers by Rui Chen in
Google Scholar
PubMed
Search for other papers by Wen Hu in
Google Scholar
PubMed
multifunctional molecule involved in immune regulation and immune diseases ( 38 , 39 , 40 ). Notably, among ARSs, leucine tRNA synthetase 1 (LARS1) has been identified as a leucine sensor upstream of the amino acid sensing pathway and is thus involved in the
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Search for other papers by Li Qian in
Google Scholar
PubMed
Search for other papers by Yuxiao Zhu in
Google Scholar
PubMed
Search for other papers by Yan Luo in
Google Scholar
PubMed
Search for other papers by Mu Zhang in
Google Scholar
PubMed
Search for other papers by Liping Yu in
Google Scholar
PubMed
Search for other papers by Yu Liu in
Google Scholar
PubMed
Search for other papers by Tao Yang in
Google Scholar
PubMed
positivity might suggest that immune damage is still in progress and UBE2L3 might be considered as a potential antigen-specific target for future immunotherapy. However, additional studies with larger populations are necessary to elucidate the function of UBE