Ruth Percik
Ruth Percik
Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel
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Sherwin Criseno
Sherwin Criseno
Department of Endocrinology, University Hospital Birmingham, Birmingham, UK
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Safwaan Adam
Safwaan Adam
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK
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Kate Young
Kate Young
Royal Marsden Hospital, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK
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Royal Marsden Hospital, London, UK
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Introduction Endocrinopathies are amongst the most frequent adverse events of immune checkpoint inhibitors (ICPIs). In common with all other side effects of systemic anticancer treatment, they are currently reported according to the Common
Hanna Karhapää
Hanna Karhapää
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Siru Mäkelä
Siru Mäkelä
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Hanna Laurén
Hanna Laurén
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Marjut Jaakkola
Marjut Jaakkola
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Camilla Schalin-Jäntti
Camilla Schalin-Jäntti
Medical Faculty, University of Helsinki, Helsinki, Finland
Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Micaela Hernberg
Micaela Hernberg
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Introduction Treatment outcomes of metastatic melanoma significantly improved after the introduction of immune checkpoint inhibitors (ICIs). By binding to their ligands, they prevent inhibitory signals, enhance the proliferation of T
Kaili Yang
Kaili Yang
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Jiarui Li
Jiarui Li
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China
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Yuejuan Cheng
Yuejuan Cheng
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Chunmei Bai
Chunmei Bai
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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64 (37.6) Treatment regimen d Drug 153 (90.0) SSA 20 (11.8) Targeted therapy 74 (43.5) Immunotherapy 20 (11.8) Immune checkpoint inhibitor 16 (9.4) Other immune modulators 4 (2
Anela Blažević
Anela Blažević
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Anand M Iyer
Anand M Iyer
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Marie-Louise F van Velthuysen
Marie-Louise F van Velthuysen
Department of Pathology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Johannes Hofland
Johannes Hofland
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Peter M van Koestveld
Peter M van Koestveld
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Gaston J H Franssen
Gaston J H Franssen
Department of Surgery, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Marina Zajec
Marina Zajec
Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Theo M Luider
Theo M Luider
Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Wouter W de Herder
Wouter W de Herder
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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Leo J Hofland
Leo J Hofland
Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands
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effect was enhanced when MAOI was used in combination with immune checkpoint anti-PD-1 treatment ( 24 ). Also, MAO-A promotes tumor-associated macrophages’ immunosuppressive functions via upregulation of oxidative stress which could be regulated by the
Kazhan Mollazadegan
Kazhan Mollazadegan
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Britt Skogseid
Britt Skogseid
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Johan Botling
Johan Botling
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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Tobias Åkerström
Tobias Åkerström
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Barbro Eriksson
Barbro Eriksson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Staffan Welin
Staffan Welin
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Anders Sundin
Anders Sundin
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Joakim Crona
Joakim Crona
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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.1159/000504392 ) 17 Young K Lawlor RT Ragulan C Patil Y Mafficini A Bersani S Antonello D Mansfield D Cingarlini S Landoni L et al . Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular
Mark J C van Treijen
Mark J C van Treijen
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Catharina M Korse
Catharina M Korse
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Wieke H Verbeek
Wieke H Verbeek
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Margot E T Tesselaar
Margot E T Tesselaar
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Gerlof D Valk
Gerlof D Valk
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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variability in individuals with SD. The tumor micro-environment is a complex ecosystem in which cancer cells interact with a diverse range of immune, stromal and endothelial cells, constantly shaping and changing the molecular biology of a tumor ( 27 ). Inter
Peiwen Wu
Peiwen Wu
Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
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Dongjie He
Dongjie He
Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China
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Hao Chang
Hao Chang
Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China
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Xiaozhi Zhang
Xiaozhi Zhang
Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
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41416-019-0606-3 ) 24 Valent F Tullio A Kara E Cipri C Sciannimanico SM Vescini F & Grimaldi F . A retrospective cohort study of histology-proven neuroendocrine neoplasms in the Italian area of Udine . Endocrine, Metabolic and Immune
Enrique Pedernera
Enrique Pedernera
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Instituto Nacional de Cancerología, Ciudad de México, México
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María J Gómora
María J Gómora
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Miguel A Almaraz
Miguel A Almaraz
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Esteban Mena
Esteban Mena
Universidad Nacional Autónoma de México, Facultad de Medicina, Secretaría General, Ciudad de México, México
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Delia Pérez-Montiel
Delia Pérez-Montiel
Instituto Nacional de Cancerología, Ciudad de México, México
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Elizabeth Rendon
Elizabeth Rendon
Hospital Militar de Especialidades de la Mujer y Neonatología. Ciudad de México, México
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Horacio López-Basave
Horacio López-Basave
Instituto Nacional de Cancerología, Ciudad de México, México
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Juan Maldonado-Cubas
Juan Maldonado-Cubas
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Carmen Méndez
Carmen Méndez
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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positivity of the immune reaction was established according to the intensity and percentage of labeled cells. Intensity was assessed as follows: 1, light; 2, medium; 3, strong. The percentage of labeling was recorded as follows: 1, 10–25%; 2, 26–50%; 3, 51
Hélène Singeisen
Hélène Singeisen
Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Mariko Melanie Renzulli
Mariko Melanie Renzulli
Institute of Radiology, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Vojtech Pavlicek
Vojtech Pavlicek
Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Pascal Probst
Pascal Probst
Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Fabian Hauswirth
Fabian Hauswirth
Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Markus K Muller
Markus K Muller
Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Magdalene Adamczyk
Magdalene Adamczyk
Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
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Achim Weber
Achim Weber
Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
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Reto Martin Kaderli
Reto Martin Kaderli
Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
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Pietro Renzulli
Pietro Renzulli
Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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MF Demonchy J Cardot-Bauters C Vantyghem MC . Multiple Endocrine Neoplasia Type 4: novel CDNK1B variant and immune anomalies . Annales d’Endocrinologie 2020 81 124 – 125 . ( https://doi.org/10.1016/j.ando.2020.04.002 ) 46 Huang KT Pavlides
