Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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as type 1 diabetes, autoimmune hypothyroidism and pernicious anaemia. Complex interplay between genetic and environmental factors gives rise to immune-mediated destruction of the steroid-producing cells of the adrenal cortex. As in type 1 diabetes
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Introduction Primary adrenal insufficiency (PAI) is a rare disease, most commonly of auto-immune origin. There is a global variation in prevalence from 80 to 145 per million in Europe, with the highest case numbers reported in Scandinavian
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half of them present with additional autoimmune diseases ( 5 , 6 , 7 ). This particular trait suggests an inborn immune defect, which potentially may be transmitted within their families. However, most of the autoimmune endocrine diseases, including
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Applied Health Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Medical Research Council London Institute of Medical Sciences, London, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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from asymptomatic infection to acute respiratory distress syndrome, multiorgan failure and death. One key negative prognostic factor for severe COVID-19 is compromised immunity and increased infection risk ( 13 ); as such, patients with PAI are assumed
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Vlachogiannis NI Paraskevis D Kaltsas GA Chrousos GP , et al. Alterations in cortisol and interleukin-6 secretion in patients with COVID-19 suggestive of neuroendocrine-immune adaptations. Endocrine 2022 75 317 – 327 . ( https://doi.org/10.1007/s12020
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Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy
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Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan Italy
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, United Kingdom
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-CoV infection leads in about 40% of cases to the development of hypocortisolism, which might be caused by direct cytopathic effects of the virus itself or by immune mediators. This leads to the suggestion that based on the similarity of SARS-CoV-2 proteins to
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Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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progenitor cells or other programming effects and may be in particular affected in girls treated until term. Moreover, functional brain networks may be altered as a result of structural changes or other effects on neurotransmitter, hormonal or immune function
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found ( Fig. 3D ). In turn, the adrenal glands of rats in the remaining control groups (sham operated ( Fig. 3B and E ) and UNX ( Fig. 3C and F )) showed a strong immune signal of β-catenin in the glomerular zone, weak or very weak immune response in
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK
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.2165/00003088-200544010-00003 ) 8 Muller L & Quinkler M . Adrenal disease: imitating the cortisol profile improves the immune system . Nature Reviews. Endocrinology 2018 14 137 – 139 . ( https://doi.org/10.1038/nrendo.2018.5 ) 9 Caldato MC Fernandes VT & Kater CE
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://doi.org/10.1038/nrendo.2011.231 ) 19 Venneri MA Hasenmajer V Fiore D Sbardella E Pofi R Graziadio C Gianfrilli D Pivonello C Negri M Naro F , Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a