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Nobuo Matsuura Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Tadashi Kaname Department of Genome Medicine, National Research Institute for Child Health and Development, Tokyo, Japan

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Norio Niikawa Health Sciences University of Hokkaido, Sapporo, Japan

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Yoshihide Ooyama Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Osamu Shinohara Shinohara Child Clinic, Machida, Japan

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Yukifumi Yokota Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Shigeyuki Ohtsu Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Noriyuki Takubo Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Kazuteru Kitsuda Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Keiko Shibayama Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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Fumio Takada Department of Medical Genetics, Kitasato University Graduate School of Medical Science, Sagamihara, Japan

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Akemi Koike Miyanosawa Child Clinic, Sapporo, Japan

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Hitomi Sano Department of Pediatric, Sapporo City General Hospital, Sapporo, Japan

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Yoshiya Ito Department of Clinical Medicine, Japanese Red Cross Hospital Collage of Nursing, Kitami, Japan

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Kenji Ishikura Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

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the subjects of this study ( Table 1 ). They were divided into three groups (iPPSD2, 4, 5) based on a novel classification proposed by the EuroPHP network, ( 12 ) that is, hormone resistance, thyroid function, hypocalcemia, the number of fingers with

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