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Long-term, real-world experience of pasireotide dose reduction in patients with acromegaly

Nelma Veronica Marques

Nelma Veronica Marques Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Luiz Eduardo Armondi Wildemberg

Luiz Eduardo Armondi Wildemberg Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Monica R Gadelha

Monica R Gadelha Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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levels under treatment with 20 mg were 1.06 × ULN, 120 mg/dL and 6.5%, respectively. HbA1c levels in most patients remained stable over time, and glucose fluctuations stabilised or decreased following pasireotide dose reduction. Overall, median glucose