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  • Metabolic Syndrome and Diabetes x
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Wei Liu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yunke Ma Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Xiaoling Cai Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yu Zhu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Mingxia Zhang Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Juan Li Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Jing Chen School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Dawei Shi School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Linong Ji Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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serum C-peptide level was associated with higher TIR and less blood glucose fluctuation recorded by CGM in children and adolescents with type 1 diabetes less than 2 years, but not with hypoglycemia ( 14 ). In another study conducted on adult type 1

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Yanmei Lou Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People’s Republic of China

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Yanyan Zhang Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Ping Zhao Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People’s Republic of China

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Pei Qin Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Changyi Wang Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Jianping Ma Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Xiaolin Peng Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Hongen Chen Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Dan Zhao Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Shan Xu Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Li Wang Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Ming Zhang Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Dongsheng Hu Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Fulan Hu Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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the U-shaped group (Supplementary Table 1). Glucose fluctuations are related to oxidative stress, endothelial dysfunction, and inflammation, which are traditionally associated with the pathogenesis of vascular damage ( 29 ); hence, decreasing FPG

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Henry Zelada Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA

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M Citlalli Perez-Guzman Internal Medicine Division of Endocrinology, Centro Médico ABC, Mexico City, Mexico

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Daniel R Chernavvsky Center for Diabetes Technology, University of Virginia, Charlottesville, Virginia, USA

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Rodolfo J Galindo Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine. Miami, Florida, USA

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glucose fluctuation is expected, such as diabetes ketoacidosis, hyperglycemic hyperosmolar state, or severe hyperglycemia with very high glucose levels (CGM maximum reporting range is often limited to 400 mg/dL), CGM use is not recommended, or clinicians

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Jan W Eriksson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Reem A Emad Department of Pharmacy, Uppsala University, Uppsala, Sweden

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Martin H Lundqvist Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Niclas Abrahamsson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Maria C Kjellsson Department of Pharmacy, Uppsala University, Uppsala, Sweden

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responses to glucose fluctuations in individuals with insulin resistance, but their respective roles need further validation in large prospective cohorts. It was previously reported that elevated counter-regulatory neuroendocrine responses to hypoglycemia

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