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serum C-peptide level was associated with higher TIR and less blood glucose fluctuation recorded by CGM in children and adolescents with type 1 diabetes less than 2 years, but not with hypoglycemia ( 14 ). In another study conducted on adult type 1
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the U-shaped group (Supplementary Table 1). Glucose fluctuations are related to oxidative stress, endothelial dysfunction, and inflammation, which are traditionally associated with the pathogenesis of vascular damage ( 29 ); hence, decreasing FPG
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glucose fluctuation is expected, such as diabetes ketoacidosis, hyperglycemic hyperosmolar state, or severe hyperglycemia with very high glucose levels (CGM maximum reporting range is often limited to 400 mg/dL), CGM use is not recommended, or clinicians
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responses to glucose fluctuations in individuals with insulin resistance, but their respective roles need further validation in large prospective cohorts. It was previously reported that elevated counter-regulatory neuroendocrine responses to hypoglycemia