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mineral density (BMD) followed by multiple low-energy fractures. In contrast to sporadic PHPT, bone disorders in patients with PHPT in multiple endocrine neoplasias (PHPT/MEN1) are more severe. The higher severity of bone and mineral disorders in patients
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soft tissue components; (ii) new SREs (pathological fractures, cord compression, surgery, or EBRT) ( 13 ); (iii) Also, when a bone lesion was measurable (with a soft tissue mass ≥10 mm), an increase of at least 20% (with at least a 5-mm increase) in the
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, spinal compression, pathologic fractures and hypercalcemia ( 7 , 9 ). In recent years, a growing interest has been directed to the prevention, diagnosis and treatment of them, and despite this, the data in this regard are still scarce. Our aim was to