Elena Valassi
Elena Valassi
Endocrinology Department, Germans Trias i Pujol Hospital and Research Institute, Badalona, Barcelona, Spain
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Iacopo Chiodini
Iacopo Chiodini
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Richard A Feelders
Richard A Feelders
Division of Endocrinology, Erasmus Medical Centre, Rotterdam, Netherlands
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Cornelie D Andela
Cornelie D Andela
Division of Endocrinology and Centre for Endocrine Tumours, Leiden University Medical Centre, Leiden, Netherlands
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Margueritta Abou-Hanna
Margueritta Abou-Hanna
HRA Pharma Rare Diseases, Châtillon, France
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Sarah Idres
Sarah Idres
HRA Pharma Rare Diseases, Châtillon, France
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Antoine Tabarin
Antoine Tabarin
Department of Endocrinology and INSERM U862 University and CHU of Bordeaux, Pessac, France
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, orthopaedic surgeons and psychiatrists identifying CS represent an educational opportunity to improve early diagnosis. It is for instance not widely known that venous thromboembolic events or fragility fractures can be a presenting symptom of CS ( 20 , 21
Dafydd Aled Rees
Dafydd Aled Rees
Cardiff University, Cardiff, United Kingdom
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Deborah P Merke
Deborah P Merke
National Institutes of Health Clinical Center and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA
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Wiebke Arlt
Wiebke Arlt
MRC LMS, London, United Kingdom
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Aude Brac De La Perriere
Aude Brac De La Perriere
Hospices Civils de Lyon - GHE - Endocrinologie, Bron, France
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Angelica Linden Hirschberg
Angelica Linden Hirschberg
Karolinska Institute, Solna, Sweden
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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John Newell-Price
John Newell-Price
The University of Sheffield, Sheffield, United Kingdom
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Alessandro Prete
Alessandro Prete
University of Birmingham, Birmingham, United Kingdom
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Nicole Reisch
Nicole Reisch
Endokrinologie, Nephrologie und weitere Sektionen - Medizinische Klinik und Poliklinik IV - Campus Innenstadt, München, Germany
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Nike M Stikkelbroeck
Nike M Stikkelbroeck
Radboud University Nijmegen, Nijmegen, Netherlands
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Philippe A Touraine
Philippe A Touraine
University Hospitals Pitié Salpêtrière - Charles Foix, Paris, France
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Alex Lewis
Alex Lewis
Neurocrine Biosciences Inc, London, United Kingdom
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John Porter
John Porter
Neurocrine Biosciences Inc, London, United Kingdom
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Helen Coope
Helen Coope
Neurocrine Biosciences Inc, London, United Kingdom
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Richard J Ross
Richard J Ross
The University of Sheffield, Sheffield, United Kingdom
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glucocorticoid dose than hydrocortisone and a significantly lower final height. Metabolic outcomes were variably reported, with some studies reporting lower cardiovascular risk factors on prednisolone but a higher incidence of osteoporosis and fractures ( 16
M Cherenko
M Cherenko
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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N M Appelman-Dijkstra
N M Appelman-Dijkstra
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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A L Priego Zurita
A L Priego Zurita
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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N R Biermasz
N R Biermasz
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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O M Dekkers
O M Dekkers
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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F A Klok
F A Klok
Department of Medicine, Division of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, Netherlands
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N Reisch
N Reisch
Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany
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A Aulinas
A Aulinas
Department of Endocrinology, Fundacio de Gestio Sanitaria Hospital de la Santa Creu i Sant Pau, IR-SantPau and CIBERER Unit 747 (ISCIII), Barcelona, Spain
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B Biagetti
B Biagetti
Department of Endocrinology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
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S Cannavo
S Cannavo
Endocrine Unit, University Hospital AOU Policlinico G. Martino, Messina, Italy
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L Canu
L Canu
University Hospital Florence Careggi, Florence, Italy
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M Detomas
M Detomas
Department of Internal Medicine, University Hospital Würzburg, Wuerzburg, Germany
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F Devuyst
F Devuyst
Department of Endocrinology, Hôpital Universitaire de Bruxelles, Hôpital Erasme, Brussels, Belgium
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H Falhammar
H Falhammar
Department of Endocrinology, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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R A Feelders
R A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, Netherlands
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F Ferrau
F Ferrau
Endocrine Unit, University Hospital AOU Policlinico G. Martino, Messina, Italy
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F Gatto
F Gatto
IRCCS Ospedale Policlinico San Martino, Genova, Genoa, Italy
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C Grasselli
C Grasselli
Cardiovascular Medicine Unit, AUSL-IRCCS, Reggio Emilia, Italy
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P van Houten
P van Houten
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, Netherlands
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C Hoybye
C Hoybye
Department of Endocrinology, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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A M Isidori
A M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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A Kyrilli
A Kyrilli
Department of Endocrinology, Hôpital Universitaire de Bruxelles, Hôpital Erasme, Brussels, Belgium
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P Loli
P Loli
Division of Endocrinology, San Raffaele Vita-Salute University, IRCCS San Raffaele Hospital Milan, Italy
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D Maiter
D Maiter
Department of Endocrinology, Cliniques universitaires Saint-Luc – UCLouvain, Brussels, Belgium
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E Nowak
E Nowak
Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany
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R Pivonello
R Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Università “Federico II” di Napoli, Naples, Italy
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O Ragnarsson
O Ragnarsson
Sahlgrenska Academy, Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine (O.R.), University of Gothenburg, Sweden
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R V Steenaard
R V Steenaard
Department of Internal Medicine, Máxima MC, Veldhoven, Netherlands
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N Unger
N Unger
University Hospital Essen, Department of Endocrinology, Diabetes and Metabolism, Essen, Germany
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A van de Ven
A van de Ven
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, Netherlands
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S M Webb
S M Webb
Department of Endocrinology, Fundacio de Gestio Sanitaria Hospital de la Santa Creu i Sant Pau, IR-SantPau and CIBERER Unit 747 (ISCIII), Barcelona, Spain
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D Yeste
D Yeste
Pediatric Endocrinology Service, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. CIBER Enfermedades Raras, Instituto Carlos III, Madrid, Spain
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S F Ahmed
S F Ahmed
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
University of Glasgow, Office for Rare Conditions, Glasgow, UK
University of Glasgow, Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, UK
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University of Glasgow, Office for Rare Conditions, Glasgow, UK
University of Glasgow, Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, UK
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A M Pereira
A M Pereira
Department of Endocrinology & Metabolism, Amsterdam University Medical Centre, Amsterdam, Noord-Holland, Netherlands
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Sex F F F M M F Age 48 55 33 54 35 39 Risk factors Overweight Hypertension Osteoporosis with fractures Obesity Hypertension Previous VTE Obesity Hypertension Repeated pituitary surgery Obesity Hypertension
Natacha Driessens
Natacha Driessens
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Madhu Prasai
Madhu Prasai
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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Christophe De Block
Christophe De Block
Department of Endocrinology-Diabetology-Metabolism, Universitair Ziekenhuis Antwerpen & University of Antwerp, Drie Eikenstraat, Edegem, Belgium
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Eva Van Caenegem
Eva Van Caenegem
Department of Endocrinology, Academisch Ziekenhuis Sint-Jan Brugge – Oostende AV, Ruddershove, Brugge, Belgium
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Guy T’Sjoen
Guy T’Sjoen
Department of Endocrinology, Ghent Universitary Hospital, C. Heymanslaan, Gent, Belgium
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Frank Nobels
Frank Nobels
Department of Endocrinology, Onze-Lieve Vrouw Ziekenhuis, Moorselbaan, Aalst, Belgium
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Christophe Ghys
Christophe Ghys
Department of Endocrinology, Universitair Ziekenhuis Brussel, Laarbeeklaan, Brussels, Belgium
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Laurent Vroonen
Laurent Vroonen
Department of Endocrinology, Cliniques Universitaires de Liège, Avenue de l’hôpital, Liège, Belgium
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Corinne Jonas
Corinne Jonas
Department of Endocrinology, CHU UCL Namur - Godinne, Avenue Docteur Gaston Thérasse, Yvoir, Belgium
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Bernard Corvilain
Bernard Corvilain
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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in 94% by DEXA scanning. Information was not available regarding osteoporotic fractures. Osteoporosis was more common in females than in males (36% vs 16%; P = 0.02). Postmenopausal status was associated with osteoporosis (88% of women with
Ditte Sofie Dahl Sørensen
Ditte Sofie Dahl Sørensen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Jesper Krogh
Jesper Krogh
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Åse Krogh Rasmussen
Åse Krogh Rasmussen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Mikkel Andreassen
Mikkel Andreassen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Medicine 2016 15 155 – 163 . ( https://doi.org/10.1016/j.jcm.2016.02.012 ) 13 Falhammar H Filipsson Nyström H Wedell A Brismar K Thorén M . Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia
Gregory Knowles
Gregory Knowles
Walsall Manor Hospital, Walsall, UK
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Emily Warmington
Emily Warmington
College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Lisa M Shepherd
Lisa M Shepherd
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Jonathan M Hazlehurst
Jonathan M Hazlehurst
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Applied Health Research, University of Birmingham, Birmingham, UK
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Institute of Applied Health Research, University of Birmingham, Birmingham, UK
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Anne de Bray
Anne de Bray
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Helena Gleeson
Helena Gleeson
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Wiebke Arlt
Wiebke Arlt
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Medical Research Council London Institute of Medical Sciences, London, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Medical Research Council London Institute of Medical Sciences, London, UK
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Alessandro Prete
Alessandro Prete
Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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– Zoledronate infusion 1 – Unknown trigger 1 5 Physical activity / 1 Had hospital admissions in the past 12 months, n (%) e 8 (9.8) 14 (17.5) d 0.174 Physical trauma/traumatic fracture 2 2 Lower
Trine Holm Johannsen
Trine Holm Johannsen
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Jakob Albrethsen
Jakob Albrethsen
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Vassos Neocleous
Vassos Neocleous
The Cyprus Institute of Neurology and Genetics, Department of Molecular Genetics, Function and Therapy, Nicosia, Cyprus
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Federico Baronio
Federico Baronio
S. Orsola-Malpighi University Hospital, Department of Medical and Surgical Sciences, Bologna, Italy
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Martine Cools
Martine Cools
Department of Pediatrics, Division of Pediatric Endocrinology, Ghent University Hospital and Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
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Lise Aksglaede
Lise Aksglaede
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Niels Jørgensen
Niels Jørgensen
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Peter Christiansen
Peter Christiansen
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Meropi Toumba
Meropi Toumba
The Cyprus Institute of Neurology and Genetics, Department of Molecular Genetics, Function and Therapy, Nicosia, Cyprus
Pediatric Endocrinology Clinic, Department of Pediatrics, Aretaeio Hospital, Nicosia, Cyprus
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Pediatric Endocrinology Clinic, Department of Pediatrics, Aretaeio Hospital, Nicosia, Cyprus
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Pavlos Fanis
Pavlos Fanis
The Cyprus Institute of Neurology and Genetics, Department of Molecular Genetics, Function and Therapy, Nicosia, Cyprus
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Marie Lindhardt Ljubicic
Marie Lindhardt Ljubicic
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Denmark
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,797 European and US men . Fertility and Sterility 2010 94 2128 – 2134 . ( https://doi.org/10.1016/j.fertnstert.2009.12.051 ) 27 Falhammar H Filipsson Nyström H Wedell A Brismar K & Thorén M . Bone mineral density, bone markers, and fractures in
Sharmin Jahan
Sharmin Jahan
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
Department of Endocrinology and Metabolism, BSMMU, Dhaka, Bangladesh
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Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
Department of Endocrinology and Metabolism, BSMMU, Dhaka, Bangladesh
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Jun Yang
Jun Yang
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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Jinbo Hu
Jinbo Hu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Peter J Fuller
Peter J Fuller
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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). Patients with PA also display an increased prevalence of metabolic syndrome and diabetes ( 6 , 7 ), osteoporotic fractures ( 8 ), and symptoms of depression with a reduced quality of life ( 9 ). When PA goes undetected, patients miss out on targeted
