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Isabelle Flechtner, Magali Viaud, Dulanjalee Kariyawasam, Marie Perrissin-Fabert, Maud Bidet, Anne Bachelot, Philippe Touraine, Philippe Labrune, Pascale de Lonlay, and Michel Polak

on the patients’ puberty onset, fertility and biological markers. Predictive factors are therefore difficult to define. The primary objective of this collaborative questionnaire survey by French Reference Centers for Rare Diseases was to collect

Open access

Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

Introduction Fertility in males is dependent on the presence of a germ cell population that is capable of developing into sperm in adulthood. However, the ability of spermatogonial stem cells (SSC) to give rise to sperm is dependent on the

Open access

Rui-yi Tang, Rong Chen, Miao Ma, Shou-qing Lin, Yi-wen Zhang, and Ya-ping Wang

odours, or a decreased ability to recognize odours, we defined the case as involving hyposmia. Histories regarding other diseases, familial histories, fertility outcomes and therapeutic management were also obtained from the records. BMI was calculated

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Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou, and David Møbjerg Kristensen

resulted in reduced birth weight while not affecting fertility ( 15 ). These data were contested in 2016, when three experimental studies in rodent were published suggesting that prenatal analgesic exposure could disrupt female reproductive development

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A Rehfeld, D L Egeberg, K Almstrup, J H Petersen, S Dissing, and N E Skakkebæk

is associated with reduced male fertility ( 28 , 29 , 30 , 31 ). An intact acrosome is required for mouse sperm cells to respond to progesterone-induced chemotaxis ( 32 ). Furthermore, only acrosome-intact human sperm cells can bind to the zona

Open access

Małgorzata Więcek, Jakub Gawlik, Zuzanna Nowak, and Aneta Gawlik

cardiovascular status, fertility preservation (FP) is one of the most important issues during the transition process in TS. With the advent of assisted reproductive technologies (ARTs), medicine brought new hope for these patients. However, due to the limited and

Open access

Rosalie Cabry, Philippe Merviel, Aicha Madkour, Elodie Lefranc, Florence Scheffler, Rachel Desailloud, Véronique Bach, and Moncef Benkhalifa

Introduction Infertility is defined as failure to obtain a clinical pregnancy after 12 months of regular, unprotected sexual intercourse. On average, it affects 8–12% of couples of child-bearing age ( 1 ). A decline in human fertility has

Open access

Luminita Nicoleta Cima, Anca Colita, and Simona Fica

in patients with different types of cancer ( 23 , 24 ). Still, the possible utility of this technique of preserving normal ovarian function and fertility in HSCT recipients has not yet been established ( 25 ). Methods This is a literature

Open access

Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch, and Elisabeth Lerchbaum

, evidence is accumulating that vitamin D deficiency is also a risk marker for insulin resistance ( 3 ), cardiovascular disease ( 4 ), infectious and autoimmune diseases ( 1 ), cancer ( 5 ), increased mortality ( 2 ) as well as decreased fertility ( 6

Open access

Katica Bajuk Studen and Marija Pfeifer

-/amenorrhea. Besides the clinical features of hyperandrogenism (hirsutism, acne, male-type baldness), oligo-/amenorrhea and impaired fertility, PCOS patients are often insulin resistant, obese and have metabolic syndrome, with arterial hypertension, dyslipidemia