Till Ittermann
Till Ittermann
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Rehman Mehmood Khattak
Rehman Mehmood Khattak
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Department of Zoology, Islamia College Peshawar (CU), Peshawar, Pakistan
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Department of Zoology, Islamia College Peshawar (CU), Peshawar, Pakistan
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Marcello R P Markus
Marcello R P Markus
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
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Jens-Peter Kühn
Jens-Peter Kühn
Institute of Radiology, University Hospital, Carl-Gustav-Carus University, Dresden, Germany
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Marie-Luise Kromrey
Marie-Luise Kromrey
Department of Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
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Giovanni Targher
Giovanni Targher
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy
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Antje Steveling
Antje Steveling
Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany
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Matthias Nauck
Matthias Nauck
Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany
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Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Healthcare GmbH). Serum levels of TSH, fT3, and fT4 levels were analyzed on the same platform by a homogeneous, sequential, chemiluminescent immunoassays based on LOCI® technology (Dimension Vista®, Siemens Healthcare GmbH). The analytical measuring range for
Ling Sun
Ling Sun
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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Wenwu Zhu
Wenwu Zhu
Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of Nanjing Medical University, Xuzhou, Jiangsu, China
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Yuan Ji
Yuan Ji
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Ailin Zou
Ailin Zou
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Lipeng Mao
Lipeng Mao
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Dalian Medical University, Dalian, Liaoning, China
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Dalian Medical University, Dalian, Liaoning, China
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Boyu Chi
Boyu Chi
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Dalian Medical University, Dalian, Liaoning, China
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Dalian Medical University, Dalian, Liaoning, China
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Jianguang Jiang
Jianguang Jiang
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Xuejun Zhou
Xuejun Zhou
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Qingjie Wang
Qingjie Wang
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Fengxiang Zhang
Fengxiang Zhang
Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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levels of thyroid-stimulating hormone (TSH) and thyroxine (T4), is a common thyroid dysfunction ( 4 , 5 ). Free T3 (FT3) plays various roles in the cardiovascular system ( 6 , 7 ). Many publications have reported that a low FT3 is associated with a poor
Qiankai Jin
Qiankai Jin
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Guoqing Huang
Guoqing Huang
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Xiaoqing Tian
Xiaoqing Tian
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Yimeng Shu
Yimeng Shu
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Ximisinuer Tusongtuoheti
Ximisinuer Tusongtuoheti
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Yushan Mao
Yushan Mao
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
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, and its evaluation in different regions and ethnicities is of importance. This study is part of the 2019 Zhejiang Zhenhai study, and the aim was to discuss the relationship between TSH, free triiodothyronine (FT3), FT4, and FT3/FT4 levels within the
Josi Vidart
Josi Vidart
Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
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Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
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Paula Jaskulski
Paula Jaskulski
Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Ana Laura Kunzler
Ana Laura Kunzler
Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Rafael Aguiar Marschner
Rafael Aguiar Marschner
Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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André Ferreira de Azeredo da Silva
André Ferreira de Azeredo da Silva
Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Simone Magagnin Wajner
Simone Magagnin Wajner
Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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units: T4 (nmol/L), T3 (nmol/L), free T4 (pmol/L), fT3 (pmol/L), and TSH (μIU/mL). The odds ratio (OR) with 95% CI for all-cause mortality were pooled using a meta-analysis. For this purpose, only studies that presented results from multiregression
Carmen Sydlik
Carmen Sydlik
Division of Pediatric Endocrinology, Center for Pediatric and Adolescent Medicine Inn-Salzach-Rott, Altoetting, Germany
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Ilja Dubinski
Ilja Dubinski
Division of Pediatric Endocrinology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Munich, Germany
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Susanne Bechtold
Susanne Bechtold
Division of Pediatric Endocrinology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Munich, Germany
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Heinrich Schmidt
Heinrich Schmidt
Division of Pediatric Endocrinology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Munich, Germany
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, as triiodothyronine/free triiodothyronine (T3/fT3) levels may be low ( 1 , 2 ). In healthy individuals, fT3 levels can be stable over a wide range of corresponding TSH levels ( 3 ). The regulation of thyroid hormones is reflected in an adjusting fT3
Yukari Maki
Yukari Maki
Department of Pediatric Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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Kiyomi Horiuchi
Kiyomi Horiuchi
Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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Takahiro Okamoto
Takahiro Okamoto
Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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showed that the levels of free triiodothyronine (fT3) and free thyroxine (fT4) were not significantly associated with the Brief Fatigue Inventory score among thyroid cancer survivors ( 16 ). A retrospective longitudinal study found that the complaints
Xiaoya Zheng
Xiaoya Zheng
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Heng Xiao
Heng Xiao
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jian Long
Jian Long
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qiang Wei
Qiang Wei
Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China
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Liping Liu
Liping Liu
Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Liping Zan
Liping Zan
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wei Ren
Wei Ren
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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free triiodothyronine (FT3), free thyroxine (FT4), ultrasensitive thyroid-stimulating hormone (uTSH), and thyroid antithyroglobulin autoantibody (TgAb) were detected with an immunochemical-automated analyzer (Beckman Coulter UniCelDxI 800; Beckman
Sílvia Santos Monteiro
Sílvia Santos Monteiro
Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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Tiago Silva Santos
Tiago Silva Santos
Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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Ana Martins Lopes
Ana Martins Lopes
Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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José Carlos Oliveira
José Carlos Oliveira
Department of Clinical Pathology, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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Cláudia Freitas
Cláudia Freitas
Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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André Couto Carvalho
André Couto Carvalho
Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal
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test following 1000 µg of oral LT4 intake ( 9 , 10 , 11 ). At the patient’s admission, a peripheral i.v. catheter was inserted and a baseline blood sample was collected for TSH, free thyroxine (FT4) and free triiodothyronine (FT3) measurements. Then
Caiyan Mo
Caiyan Mo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Tao Tong
Tao Tong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ying Guo
Ying Guo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Zheng Li
Zheng Li
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Liyong Zhong
Liyong Zhong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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serum thyroid hormone levels and suppressed TSH, diffuse enlargement of the thyroid gland, and TRAb are positive. Laboratory methods Fasting serum GH, IGF-1, total triiodothyronine (TT3), total thyroxine (TT4), TSH, free triiodothyronine (FT3
Heleen I Jansen
Heleen I Jansen
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Marijn M Bult
Marijn M Bult
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Peter H Bisschop
Peter H Bisschop
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Annemieke C Heijboer
Annemieke C Heijboer
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Jacquelien J Hillebrand
Jacquelien J Hillebrand
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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concentrations may be relevant for evaluating treatment effects if TSH cannot be used as a marker to monitor thyroidal status (e.g. in central hypothyroidism). Furthermore, a higher fT4/fT3 ratio was seen in patients using L-T4 compared to healthy controls ( 12
