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Department of Nutrition, Institute of Life Sciences, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil
Department of Nutrition, Faculty of Health and Medical Sciences, University of Surrey, University of Surrey, Guildford, UK
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exposure of the skin to UV rays, whilst it can also be ingested through diet ( 1 , 2 , 3 ). Over the past two decades, there has been intensifying robust scientific evidence that vitamin D inadequacy is a significant public health issue not only across
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hypercalcemia, which induced significant alterations in the cardiac function, although the increase in calcium independent of vitamin D did not reveal this effect. Furthermore, important evidence has shown that vitamin D receptors in the brain may be
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)D elevation. Therefore, there is contradictory evidence regarding this issue, and the accurate relationship between vitamin D and adiposity indicators remains unclear. According to the results of the studies included in the systematic review, overweight and
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situ ( 35 ). Additional support for the importance of this mechanistic evidence comes from the fact that increased intakes are needed in overweight/obese subjects (by ×1.5 to ×3 or ×4-fold) as compared to the intakes needed by slim people to achieve
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
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Université Paris-Saclay, Inserm U1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Service d’Endocrinologie et Diabète de l’Enfant, Centre de Référence des Maladies Rares du Calcium et du Phosphore et Filière de Santé Maladies Rares OSCAR, Hôpital Bicêtre Paris Saclay, Le Kremlin-Bicêtre, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Assistance Publique-Hôpitaux de Paris, Institut Necker-Enfants Malades, INSERM U1151 – CNRS UMR 8253, Paris, France
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Association Francophone de Chirurgie Endocrinienne (AFCE), France
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Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Biochimie et Génétique Moléculaires, Paris, France
INSERM, U1169, Université Paris Sud, Hôpital Bicêtre, Le Kremlin Bicêtre, France
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INSERM, U1418, CIC-EC, Hôpital Européen Georges Pompidou, Paris, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
CNRS, ERL8228, Paris, France
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standardize the care of hypoparathyroidism in light of evidence-based recommendations and to raise issues and interest in future investigations. None of these initiatives fully addresses the management of children with hypoparathyroidism. Due to the huge
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Introduction In adults from Westernized societies, the arterial system is the second most mineralized site after the skeleton, and there is increasing evidence of a reciprocal regulation between the calcification of both systems ( 1 , 2 ). In
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was no evidence of significant growth or hormone overproduction. However, 3 years after diagnosis, two lesions were detected in the liver and in the rib. Treatment with somatostatin analogs was initiated 2 years ago and the disease remained stable ever
Fondazione Italiana Ricerca sulle Malattie dell’Osso (FIRMO Onlus), Florence, Italy
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status has also been linked to muscle strength in older people ( 7 ) and the incidence of falls ( 8 ). There is also evidence of a beneficial effect of vitamin D on bone mineral density (BMD) ( 1 ) and a range of extraskeletal effects including benefits
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Fgf23 knockout mice reversed the hypervitaminosis D (from high serum 1,25(OH) 2 D 3 levels to low serum levels) that was consistently noted in fgf23 knockout mice ( 37 ), again providing an in vivo evidence of FGF23 and vitamin D interactions. An
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/A, not applicable; TNM staging systems for PC by Schulte: T1, evidence of capsular invasion; T2, invasion of surrounding soft tissues excluding the vital organs trachea, larynx, and esophagus; T3, evidence of vascular invasion; T4, invasion of vital