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Lára Ósk Eggertsdóttir Claessen
Lára Ósk Eggertsdóttir Claessen
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Hafrún Kristjánsdóttir
Hafrún Kristjánsdóttir
Physical Activity, Physical Education, Sport, and Health (PAPESH) Research Centre, Sports Science Department, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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María Kristín Jónsdóttir
María Kristín Jónsdóttir
Mental Health Services, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Sigrún Helga Lund
Sigrún Helga Lund
deCODE Genetics, Inc/Amgen Inc., Reykjavik, Iceland
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Ingunn Unnsteinsdóttir Kristensen
Ingunn Unnsteinsdóttir Kristensen
Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Helga Ágústa Sigurjónsdóttir
Helga Ágústa Sigurjónsdóttir
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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, s-prolactin, serum cortisol (s-cortisol), serum follicle-stimulating hormone (s-FSH), serum luteinizing hormone (s-LH), serum estrogen (s-estrogen) and serum progesterone (s-progesterone). If the first SBT was O-RV for each hormone ( Table 1 ), the
Ichelle Maa van Roessel
Ichelle Maa van Roessel
Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, AB Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Boudewijn Bakker
Boudewijn Bakker
Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, AB Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Hanneke M van Santen
Hanneke M van Santen
Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, AB Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Wassim Chemaitilly
Wassim Chemaitilly
Division of Pediatric Endocrinology, UPMC Children’s Hospitalof Pittsburgh, Pittsburgh, Pennsylvania, USA
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pubertal development during adolescence and help prevent the negative consequences of low testosterone or estrogen levels such as fatigue, decreased muscle strength and decreased bone density later in life ( 45 ). Premature ovarian insufficiency (POI) is
Kevin C J Yuen
Kevin C J Yuen
Departments of Neuroendocrinology and Neurosurgery, Barrow Neurological Institute, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona, United States
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Gudmundur Johannsson
Gudmundur Johannsson
Department of Endocrinology, Sahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Ken K Y Ho
Ken K Y Ho
The Garvan Institute of Medical Research and the Faculty of Medicine, University of New South Wales, Sydney, Australia
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Bradley S Miller
Bradley S Miller
Pediatric Endocrinology, University of Minnesota Medical School, M Health Fairview Masonic Children’s Hospital, Minneapolis, Minnesota, United States
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Ignacio Bergada
Ignacio Bergada
Centro de Investigaciones Endocrinológicas "Dr César Bergadá" (CEDIE), CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina
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Alan D Rogol
Alan D Rogol
Pediatric Diabetes and Endocrinology, University of Virginia, Charlottesville, Virginia, United States
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decreases GH secretion ( 11 ). In men, estrogens derived from paracrine aromatization of androgens are responsible for driving the central secretion of GH, independent of the androgen receptor, whereas in women, the evidence supporting a role for estrogen in
Laura Chioma
Laura Chioma
Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Carla Bizzarri
Carla Bizzarri
Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Martina Verzani
Martina Verzani
Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Daniela Fava
Daniela Fava
Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Mariacarolina Salerno
Mariacarolina Salerno
Paediatric Endocrinology Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
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Donatella Capalbo
Donatella Capalbo
Paediatric Endocrinology Unit, Department of Mother and Child, University Hospital Federico II, Naples, Italy
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Chiara Guzzetti
Chiara Guzzetti
Paediatric Endocrine Unit, Paediatric Hospital Microcitemico ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Laura Penta
Laura Penta
Pediatric Clinic, Department of Medicine and Surgery, University of Perugia, Perugia, Italy
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Luigi Di Luigi
Luigi Di Luigi
Endocrinology Unit, Department of Movement, Human and Health Sciences, University of Rome ‘Foro Italico’, Rome, Italy
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Natascia di Iorgi
Natascia di Iorgi
Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Mohamad Maghnie
Mohamad Maghnie
Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Sandro Loche
Sandro Loche
Paediatric Endocrine Unit, Paediatric Hospital Microcitemico ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Marco Cappa
Marco Cappa
Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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ultrasound was performed to assess uterine diameters and the endometrium pattern. A uterine longitudinal diameter >34 mm was considered suggestive of estrogenic stimulation and incipient puberty. The majority of children in the CPP subgroups (22/37 in 2019
Stefan M Constantinescu
Stefan M Constantinescu
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Thierry Duprez
Thierry Duprez
Department of Radiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Edward Fomekong
Edward Fomekong
Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Christian Raftopoulos
Christian Raftopoulos
Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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. Gonadotropin insufficiency was defined, in men, by a low morning testosterone level on two separate occasions along with low or low normal LH and FSH; in premenopausal women, by oligomenorrhea or amenorrhea and low estrogen levels along with low or low normal
Mette Marie Baunsgaard
Mette Marie Baunsgaard
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Anne Sophie Lind Helligsoe
Anne Sophie Lind Helligsoe
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Louise Tram Henriksen
Louise Tram Henriksen
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Torben Stamm Mikkelsen
Torben Stamm Mikkelsen
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Michael Callesen
Michael Callesen
Department of Paediatrics, Odense University Hospital, Odense, Funen, Denmark
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Britta Weber
Britta Weber
The Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
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Henrik Hasle
Henrik Hasle
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Niels Birkebæk
Niels Birkebæk
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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–61) 54 (40–56) Time from irradiation to GH treatment, years Median (range) 2.6 (0.5–7.9) 5.6 (1.2–7.9) a Includes estrogen and testosterone. GH, growth hormone; ITT, insulin tolerance test. Endocrinopathies
I M A A van Roessel
I M A A van Roessel
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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J E Gorter
J E Gorter
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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B Bakker
B Bakker
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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M M van den Heuvel-Eibrink
M M van den Heuvel-Eibrink
Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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M H Lequin
M H Lequin
Department of Radiology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J van der Lugt
J van der Lugt
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
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L Meijer
L Meijer
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
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A Y N Schouten-van Meeteren
A Y N Schouten-van Meeteren
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
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H M van Santen
H M van Santen
Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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had entered puberty at follow-up, 14 were currently treated with puberty inhibition and four with estrogen or testosterone suppletion. At follow-up, 13.2% (17/129) of children had a height SDS below −2.0. Normal weight was present in 52.9% (81
Saroj Kumar Sahoo
Saroj Kumar Sahoo
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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Jayakrishnan C Menon
Jayakrishnan C Menon
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Nidhi Tripathy
Nidhi Tripathy
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Monalisa Nayak
Monalisa Nayak
Department of Liver Intensive Care Unit, King’s College Hospital, London, UK
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Subhash Yadav
Subhash Yadav
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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pre-existing pituitary or adrenal disease were excluded from the study. Those who were using medications affecting cortisol-binding globulin (estrogens) were also excluded from the study. Three hundred and two patients (median age 54 years
Clara Lundetoft Clausen
Clara Lundetoft Clausen
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Trine Holm Johannsen
Trine Holm Johannsen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Niels Erik Skakkebæk
Niels Erik Skakkebæk
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Hanne Frederiksen
Hanne Frederiksen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Camilla Koch Ryrsø
Camilla Koch Ryrsø
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Arnold Matovu Dungu
Arnold Matovu Dungu
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Maria Hein Hegelund
Maria Hein Hegelund
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Daniel Faurholt-Jepsen
Daniel Faurholt-Jepsen
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Rikke Krogh-Madsen
Rikke Krogh-Madsen
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Birgitte Lindegaard
Birgitte Lindegaard
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Allan Linneberg
Allan Linneberg
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Line Lund Kårhus
Line Lund Kårhus
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Thomas Benfield
Thomas Benfield
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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estrogen, this was chosen for analysis in the population. In women, testosterone concentrations were discretely, albeit statistically significantly, lower in patients in the two COVID-19 cohorts as well as in patients with bacterial CAP and influenza
