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peroxisome proliferator-activated receptor (PPAR) γ/α, estrogen receptor α (ER-α), activator protein-2α (AP-2α), and SP1 ( 9 , 12 , 32 , 33 ). The regulation of MPO expression and serum MPO levels is a complicated network that includes age, gender, and
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women (37.31%) than in men (Supplementary Table 5), which may bias the conclusions. Second, male and female estrogen levels differ, and lower endogenous estrogen levels in men than in women may lead to stronger insulin resistance ( 32 ). Insulin
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Franchitto A Onori P Glaser SS Alpini G Francis H Marucci L Sterpetti P Ginanni-Corradini S Estrogens and insulin-like growth factor 1modulate neoplastic cell growth in human cholangiocarcinoma . American Journal of Pathology 2006 169 877
Department of Endocrinology, Austin Health, Melbourne, Australia
Division of Endocrinology, Diabetes and Metabolism, Northwell, Great Neck, New York, USA
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(Department of Gastroenterology, Austin Health, Melbourne, Australia) for conducting the FibroScans for our participants. References 1 Nadji M Gomez-Fernandez C Ganjei-Azar P & Morales AR . Immunohistochemistry of estrogen and progesterone