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external stimuli present in organismal model systems. For example, a 40-min exposure to estrogen in human umbilical vein endothelial cell culture leads to an acute PI3K-mediated upregulation of 250 genes ( 30 ). GR ChIP-seq studies have shown a significant
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-keepers of tissue glucocorticoid action . Physiological Reviews 2013 93 1139 – 1206 . ( https://doi.org/10.1152/physrev.00020.2012 ) 30 Oelkers WK . Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure . Steroids