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Introduction
Neuroendocrine tumors (NETs) are rare neoplasms that occur in various locations throughout the body. Despite their usually benign character, they might manifest with distant metastases. N-terminal prohormone of brain natriuretic peptide (NT-proBNP) has previously been described as a useful biomarker in diagnosing carcinoid heart disease (CHD), a common advanced NETs manifestation. We observed plasma concentrations of NT-proBNP in metastatic midgut NETs over a 4-year period.
Objectives
We aimed to explore NT-proBNP concentrations in states of varying levels of cell proliferation and disease status. Our goal was to investigate NT-proBNP’s role in predicting disease progression in relation to previous research and up-to-date scientific guidelines.
Patients and methods
We performed a retrospective multivariate analysis of NT-proBNP concentrations in 41 midgut NETs patients treated with somatostatin analogs, all with liver metastases. NT-proBNP concentrations were measured in every patient across 16 evenly distanced time points over a 48-month period and were compared to variables such as sex, age, grading, Ki-67, primary tumor location, and CT findings.
Results
NT-proBNP concentrations correlated positively with higher liver tumor burden, higher grading, high Ki-67 levels, and with progressive disease in CT. There were no differences in NT-proBNP levels with regard to primary location (ileum vs jejunum), sex, and age.
Conclusion
We conclude that NT-proBNP is a useful analyte for monitoring NETs progression, due to its increased concentration in scenarios implying increased cellular proliferation. These long-term follow-up results align with previous findings and suggest an additional role for NT-proBNP in diagnostic algorithms, beyond a CHD biomarker.
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Introduction Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), is a global health issue affecting millions of individuals worldwide, with its prevalence continually escalating ( 1 ). T2DM is associated with a multitude of
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, height, weight, smoking status, drinking status, physical activity, medical history (diabetes mellitus, dyslipidemia, myocardial infarction, stroke, etc.), and laboratory markers (total cholesterol, high-density lipoprotein cholesterol (HDL-C), low
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
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homeostasis ( 1 ). In addition to being associated with poor musculoskeletal health, vitamin D deficiency is associated with obesity, hypertension, dyslipidemia, diabetes mellitus, metabolic syndrome, and cardiovascular diseases ( 2 , 3 , 4 , 5 , 6
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Department of Cardiology, Yanbian University Hospital, Yanji, China
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inhibitors have been used in the treatment of type II diabetes mellitus (T2MD) to block the degradation and inactivation of GLP-1 ( 14 ). All animals, male and female, were kept in a clean, well-ventilated, and well-lighted environment with a temperature of
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factors such as liver dysfunction and diabetes mellitus, our study found that the serum fetuin-B levels of patients with essential hypertension were higher than those of healthy controls. In general population, we observed that serum fetuin-B levels were
Department of Endocrinology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
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, dyslipidemia, diabetes mellitus, history of hypokalemia, PAC, renin, and ARR. The hormone parameters were classified as categorical variables around the median. For all hypertensive patients, univariate logistic regression analysis revealed that older age
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Steno Diabetes Centre Odense, Odense University Hospital, Odense, Denmark
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Steno Diabetes Centre Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Steno Diabetes Centre Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Steno Diabetes Centre Aarhus, Aarhus University Hospital, Aarhus, Denmark
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. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation . Diabetic Medicine: a Journal of the British Diabetic Association 1998 15
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Internal Medicine, Lillebaelt Hospital, Kolding, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Haematology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
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criteria included prior thrombosis, current anticoagulation therapy or use of platelet inhibitors, current use of narcotics, diabetes mellitus, and prior severe head trauma. Male controls with total testosterone levels below the assay reference were
