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Philippe Jean-Luc Gradidge
Philippe Jean-Luc Gradidge
Centre for Exercise Science and Sports Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Nicole G Jaff
Nicole G Jaff
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Shane A Norris
Shane A Norris
SAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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Marketa Toman
Marketa Toman
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Nigel J Crowther
Nigel J Crowther
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Africa. BT20 plus is supported by the Wellcome Trust and Gates Foundation. S A N is supported by the DSI-NRF Centre of Excellence in Human Development at the University of the Witwatersrand, Johannesburg, South Africa. Author contribution statement
Xiaohui Qi
Xiaohui Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ping He
Ping He
Shanghai Hospital Link Center, Shanghai Hospital Development Center, Shanghai, China
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Huayan Yao
Huayan Yao
Computer Net Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Huanhuan Sun
Huanhuan Sun
Wonders Information Co. Ltd, Shanghai, China
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Jiying Qi
Jiying Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Min Cao
Min Cao
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Bin Cui
Bin Cui
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Guang Ning
Guang Ning
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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shown that insulin and insulin-like growth factor (IGF) are involved in the development and progression of malignancies ( 9 , 10 ). Insulin has been reported to be associated with an increased risk of several cancer sites, such as the liver, pancreas
Xiaohui Weng
Xiaohui Weng
School of Mechanical and Aerospace Engineering, Jilin University, Changchun, China
Weihai Institute for Bionics, Jilin University, Weihai, China
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Weihai Institute for Bionics, Jilin University, Weihai, China
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Gehong Li
Gehong Li
School of Mathematics, Jilin University, Changchun, China
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Ziwei Liu
Ziwei Liu
Department of endocrinology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China
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Rui Liu
Rui Liu
Department of VIP Unit, China-Japan Union Hospital of Jilin University, Changchun, China
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Zhaoyang Liu
Zhaoyang Liu
Digital Intelligent Cockpit Department, Intelligent Connected Vehicle Development Institute, China FAW Group Co LTD, Changchun, China
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Songyang Wang
Songyang Wang
Digital Intelligent Cockpit Department, Intelligent Connected Vehicle Development Institute, China FAW Group Co LTD, Changchun, China
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Shishun Zhao
Shishun Zhao
School of Mathematics, Jilin University, Changchun, China
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Xiaotong Ma
Xiaotong Ma
School of Mathematics, Jilin University, Changchun, China
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Zhiyong Chang
Zhiyong Chang
Weihai Institute for Bionics, Jilin University, Weihai, China
College of Biological and Agricultural Engineering, Jilin University, Changchun, China
Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China
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College of Biological and Agricultural Engineering, Jilin University, Changchun, China
Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China
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conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This work was supported by the National Natural Science Foundation of China (51875245), the Science-Technology Development Plan Project of Jilin
Nobuo Matsuura
Nobuo Matsuura
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Tadashi Kaname
Tadashi Kaname
Department of Genome Medicine, National Research Institute for Child Health and Development, Tokyo, Japan
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Norio Niikawa
Norio Niikawa
Health Sciences University of Hokkaido, Sapporo, Japan
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Yoshihide Ooyama
Yoshihide Ooyama
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Osamu Shinohara
Osamu Shinohara
Shinohara Child Clinic, Machida, Japan
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Yukifumi Yokota
Yukifumi Yokota
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Shigeyuki Ohtsu
Shigeyuki Ohtsu
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Noriyuki Takubo
Noriyuki Takubo
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Kazuteru Kitsuda
Kazuteru Kitsuda
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Keiko Shibayama
Keiko Shibayama
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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Fumio Takada
Fumio Takada
Department of Medical Genetics, Kitasato University Graduate School of Medical Science, Sagamihara, Japan
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Akemi Koike
Akemi Koike
Miyanosawa Child Clinic, Sapporo, Japan
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Hitomi Sano
Hitomi Sano
Department of Pediatric, Sapporo City General Hospital, Sapporo, Japan
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Yoshiya Ito
Yoshiya Ito
Department of Clinical Medicine, Japanese Red Cross Hospital Collage of Nursing, Kitami, Japan
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Kenji Ishikura
Kenji Ishikura
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
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JC Rothenbuhler A Lingart A . Progressive development of PTH resistance in patients with inactivating mutations on the maternal allele of GNAS . Journal of Clinical Endocrinology and Metabolism 2017 102 1844 – 1850 . ( https://doi.org/10
Weiwei He
Weiwei He
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Caoxin Huang
Caoxin Huang
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiulin Shi
Xiulin Shi
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Menghua Wu
Menghua Wu
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Han Li
Han Li
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Qiuhong Liu
Qiuhong Liu
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiaofang Zhang
Xiaofang Zhang
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Yan Zhao
Yan Zhao
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xuejun Li
Xuejun Li
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China
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imbalance between ECM synthesis and degradation can lead to the development of liver fibrosis ( 16 , 17 , 18 ). Activation of the HSCs is currently regarded as a central event in liver fibrosis ( 19 , 20 ). Studies over the last two decades have shown
Qian Deng
Qian Deng
Graduate College of Anhui University of Chinese Medicine, Hefei, China
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Yue Zhu
Yue Zhu
Graduate College of Anhui University of Chinese Medicine, Hefei, China
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Mengmeng Zhang
Mengmeng Zhang
Graduate College of Anhui University of Chinese Medicine, Hefei, China
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Aihua Fei
Aihua Fei
Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
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Jiaqi Liang
Jiaqi Liang
Graduate College of Anhui University of Chinese Medicine, Hefei, China
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Jinjin Zheng
Jinjin Zheng
Graduate College of Anhui University of Chinese Medicine, Hefei, China
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Qingping Zhang
Qingping Zhang
College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China
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Tong Cheng
Tong Cheng
Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China
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Xia Ge
Xia Ge
Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
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observations demonstrated that the activation of the Nrf2/GPX4 axis could protect β cells from ferroptosis. Collectively, the occurrence and development of diabetes may be tightly associated with ferroptosis. Overview of ferroptosis Ferroptosis is an
Ying Pei
Ying Pei
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Rui Wang
Rui Wang
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Wanyu Chen
Wanyu Chen
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Shulin Yi
Shulin Yi
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Chen Huang
Chen Huang
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Shaochan Liang
Shaochan Liang
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Hongying Cao
Hongying Cao
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Yifei Xu
Yifei Xu
Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China
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Bo Tan
Bo Tan
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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intestinal motility ( 13 ). The gut microbiota plays a pivotal role in ENS development and physiological function ( 14 ). Germ-free mice exhibited abnormalities in ENS morphology and activity ( 15 ). The interaction between gut microbiota and ENS has been
Yang Yu
Yang Yu
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Hairong Hao
Hairong Hao
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Linghui Kong
Linghui Kong
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Jie Zhang
Jie Zhang
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Feng Bai
Feng Bai
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Fei Guo
Fei Guo
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Pan Wei
Pan Wei
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Rui Chen
Rui Chen
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Wen Hu
Wen Hu
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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development of metabolic diseases, but the causal relationship and mechanism between BCAAs and cardiometabolic diseases are still not fully understood. In this study, the elevation of BCAAs occurred earlier than other metabolic disorders. To better reveal the
Svjatoslavs Kistkins
Svjatoslavs Kistkins
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Othmar Moser
Othmar Moser
Division of Exercise Physiology and Metabolism, Institute of Sport Science, University of Bayreuth, Bayreuth, Germany
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Vitālijs Ankudovičs
Vitālijs Ankudovičs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Dmitrijs Blizņuks
Dmitrijs Blizņuks
Institute of Smart Computing Technologies, Riga Technical University, Riga, Latvia
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Timurs Mihailovs
Timurs Mihailovs
Institute of Smart Computing Technologies, Riga Technical University, Riga, Latvia
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Sergejs Lobanovs
Sergejs Lobanovs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Harald Sourij
Harald Sourij
Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetolgoy, Medical University of Graz, Graz, Austria
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Andreas F H Pfeiffer
Andreas F H Pfeiffer
Department of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm, Berlin, Germany
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Valdis Pīrāgs
Valdis Pīrāgs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
Faculty of Medicine, University of Latvia, Riga, Latvia
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Faculty of Medicine, University of Latvia, Riga, Latvia
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, retatrutide was demonstrated in obese people to reduce body weight by up to 24.2% over 48 weeks ( 12 ). In addition, dual agonists, combining GLP1 and glucagon receptor activation are currently under development, of which survodutide (BI 456906) was shown to
Annalisa Blasetti
Annalisa Blasetti
Department of Paediatrics, University of Chieti, Chieti, Italy
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Valeria Castorani
Valeria Castorani
Department of Paediatrics, University of Chieti, Chieti, Italy
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Nella Polidori
Nella Polidori
Department of Paediatrics, University of Chieti, Chieti, Italy
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Ilaria Mascioli
Ilaria Mascioli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Francesco Chiarelli
Francesco Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Cosimo Giannini
Cosimo Giannini
Department of Paediatrics, University of Chieti, Chieti, Italy
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anthropometric development in children with T1D ( 1 , 2 ). The Mauriac syndrome, characterized by growth failure and hepatomegaly, constitutes the most critical growth-related condition characterized by long-term and poorly controlled T1D in relation to chronic
