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intracellular signaling. Mutations in the menin gene cause the development of multiple endocrine neoplasia type 1 (MEN1) syndrome. This autosomal dominant disease is characterized by the formation of multiple tumors, predominantly located in the endocrine glands
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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hypogonadism, it is associated with the development of obesity, insulin resistance, hyperinsulinemia, and increased cardiovascular disease risk ( 1 , 2 ). The metabolic syndrome is present in >50% of men receiving long-term ADT compared to 20% of matched
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well established that SI-NETs secrete a wide array of bioactive molecules, with a central role for the bioamine serotonin ( 2 , 3 ). Serotonin signaling is involved in various biological processes. Importantly, it can promote fibrosis development in
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time between cancer treatments, and the development of sequelae. This has been compounded by relatively few studies investigating the underlying pathophysiology of late effects and lower levels of research funding compared to other areas of oncology
Faculty of Medicine Division 2, Internal Medicine Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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Faculty of Medicine Division 2, Internal Medicine Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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Department of Paediatrics, UMHAT ‘Sveta Marina’ Varna, Medical University of Varna, Varna, Bulgaria
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& Genetic Obesity Syndromes; MTG6 Hypothalamic and Pituitary Conditions; MTG7 Sex Development & Maturation, and MTG8 Thyroid. The CPMS is a virtual consultation platform, made specifically for ERNs, which complies with the General Data Protection
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Amsterdam UMC, Emma’s Children’s Hospital, Amsterdam, The Netherlands
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developed in order to facilitate the development of a personalized care plan and to improve the quality of LTFU care. Childhood cancer care is typically provided in a pediatric cancer center where follow-up continues until the risk of recurrence is
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Royal Marsden Hospital, London, UK
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available guidelines and summary of product characteristics on ICPI-IE recommend checking thyroid function on each cycle of treatment, and changes in TSH ( 13 ) and free T4 ( 18 ) have been shown to precede the development of pan-hypopituitarism in those
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands
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Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands
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, and differentiation ( 3 ). Alterations in TH bioavailability have been implicated in the development of several forms of cancer, including basal cell carcinomas ( 4 ), lung cancer ( 5 , 6 ), and colorectal cancer (CRC) ( 7 ). CRC is one of the world
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because they share the same appearance of inflammatory background ( 9 ). The development of thyroidal MALT lymphoma has been described as an adverse event in patients suffering from long-standing HT ( 23 ). Differently, autoimmune thyroiditis is included
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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as the primary risk factor in the development of obesity in CBTS ( 24 ). In keeping with this finding the authors showed hypothalamic tumour location, hypothalamic irradiation doses > 51 Gy and endocrinopathies (particularly GHD) to be associated with