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Department of Pediatric Neuro-Oncology, Prinses Máxima Centrum, Utrecht, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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effects like depression, anxiety, mania, delirium and even suicidality. Cognitive and memory impairments and sleep disturbances are also well-known side effects ( 4 , 5 ). The high prevalence of the potentially severe adverse effects makes it important to