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hepatic glucose and lipid metabolism by direct and indirect mechanisms ( 1 ). For example portal insulin acts on the liver to directly activate glycogen synthesis and de novo lipogenesis (DNL) and inhibit gluconeogenesis, whilst peripherally insulin may
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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of carbohydrates leading to de novo lipogenesis) ( 2 , 13 , 23 , 24 , 25 , 26 ). Nevertheless, some endocrine diseases are also associated with NAFLD and NASH ( Table 1 ), and their pathophysiology will be discussed. Table 1 Endocrine
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novo lipogenesis ( 21 ). Results of microarray analysis showed that pathways associated with pyruvate metabolism and TCA cycle were down-regulated, meaning that the de novo lipogenesis is suppressed, which in turn leads to the decrease of fat
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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hepatic de novo lipogenesis and may serve as a biomarker of NAFLD progression ( 21 ). Here, we combined two datasets from GSE database and found that hepatic IGFBP-2 expression as a hub gene was also reversely associated with steatosis and serum ALT
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hypothyroidism. The altered functions are labeled in the presence of hypothyroidism. Red arrows mark actions of declined TH, and blue arrows mark actions of elevated TSH. TH decreases in hypothyroidism and then de novo lipogenesis (DNL) and the activity of HMG
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de novo lipogenesis . International Journal of Obesity and Related Metabolic Disorders 2004 28 ( Supplement 4 ) S3 – S11 . ( https://doi.org/10.1038/sj.ijo.0802852 ) 10.1038/sj.ijo.0802852) 13 Henderson GC Fattor JA Horning MA Faghihnia
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lipid export or degradation is exceeded by lipid import or synthesis. Main sources of hepatic lipid aggregation are a flux of free fatty acids (FFA) from peripheral adipose tissue (59%), followed by hepatic de novo lipogenesis (26%) and dietary intake
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High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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hyperlipidemia, hyperinsulinemia and hyperglycemia ( 71 ). It remains to be investigated whether this is due to increased lipid oxidation promoted by GH and IGF-1 or due to alterations in hepatic lipid metabolism, i.e. de novo lipogenesis and lipolysis
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triglycerides contained in circulating very low density lipoproteins and chylomicrons, fatty acids derived from adipose tissue lipolysis or de novo lipogenesis, which is the production of fatty acids from acetyl CoA that is mainly derived from glucose
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Expert Panel Statement . Metabolism: Clinical and Experimental 2017 71 17 – 32 . ( https://doi.org/10.1016/j.metabol.2017.02.014 ) 32 Softic S Cohen DE Kahn CR Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease