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, calcium metabolic disorder, hypercalciuria ( 7 , 8 , 9 , 10 ), and acidic urine ( 11 ) and can promote the development of kidney stone disease. Clinically, patients with PA are reported to have a higher incidence of urolithiasis and larger kidney stones
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sphingolipids, ceramide and sphingosine, on steroidogenesis. S1P exerts its effects through five G protein coupled receptors (S1PR 1-5 ), and its stimulation of downstream inositol triphosphate and calcium signalling can stimulate steroidogenesis ( 34 ). The
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% or - PAC: 13 ng/dL Not applicable 0.754 70.1% 72.4% Okamoto R, et al. /2018/Japan ( 46 ) PA = 101 EH = 27 - Recruited patients only on calcium channel antagonists and/or alpha-blockers as antihypertensive drugs 50 mg 60 and 90
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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L Zarnegar R . Both preoperative alpha and calcium channel blockade impact intraoperative hemodynamic stability similarly in the management of pheochromocytoma . Surgery 2014 156 1410 – 1417 ; discussion 1417 . ( https://doi.org/10.1016/j
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manufacturer’s instruction. In brief, cells were harvested and resuspended to a density of 1.5 × 10 6 cells/mL in assay buffer (calcium and Mmgnesium-free PBS), 5 mM HEPES, 0.1% BSA, 0.5 mM IBMX). The cell suspension (7500 cells in 5 μL) was dispensed into
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(30.7) 102 (29.0) 0.753 Beta blockers 137 (31.1) 33 (37.5) 104 (29.6) 0.149 Calcium blockers 259 (58.9) 60 (68.2) 199 (56.5) 0.047 Diuretics 165 (37.5) 35 (39.8) 130 (36.9) 0.622 Other drugs