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Wellcome-MRC Institute of Metabolic Science, University of Cambridge & Addenbrooke’s Hospital, Cambridge Biomedical Campus, Cambridge, UK
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Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK
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Pituitary Society
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antidiuretic actions of posterior pituitary extracts were discovered in the late 19th and early 20th centuries, including the use of posterior pituitary extracts to treat diabetes insipidus. In the mid-20th century, arginine vasopressin (AVP) was synthesized
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Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
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Steno Diabetes Center Aarhus (SDCA), Aarhus University Hospital, Aarhus, Denmark
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). The polyuria of PPS is characterized by a high output of hypotonic urine ( 2 ) and includes four conditions: arginine vasopressin (AVP) deficiency, nephrogenic diabetes insipidus, primary polydipsia, and gestational diabetes insipidus. The water
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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University Center of Cardiovascular Science & Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg–Kiel–Lübeck, Hamburg, Germany
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) ( 18 , 20 , 21 , 22 ) being characterized by an imbalanced arginine vasopressin (AVP) secretion ( 23 ). The exact pathophysiological mechanism leading to SIAD in these patients remains elusive, although the contribution of interleukin-6 (IL-6) is
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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approach). However, most patients have a risk of developing arginine vasopressin deficiency after surgery ( 1 , 2 ). Therefore, sufficient hydration is needed to maintain fluid balance. In some cases, however, negative fluid balances still occur. The most
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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, including arginine vasopressin deficiency (diabetes insipidus (DI)) with adipsia) ( 6 , 7 , 8 , 9 ). Disturbed hunger and satiety feelings in combination with decreased energy expenditure can result in morbid obesity, with the clinical picture being very
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of arginine and proline metabolism ( 42 , 43 ). Besides, arginine, the component of arginine vasopressin (AVP), plays a pivotal role in regulating blood pressure. It has been demonstrated that abnormal AVP levels could severely promote portal
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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deficiency 27.8% (10/36) 15.9% (10/63) 0.156 LH/FSH deficiency 2.8% (1/36) 3.2% (2/63) 0.912 Arginine vasopressin deficiency with thirst feeling 11.1% (4/36) 6.3% (4/63) 0.457 Arginine vasopressin deficiency without
Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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last visit +0.73 –0.03 +0.95 Presurgical grade of HI (3) II I II Grade of surgical HL (3) I I 0 Irradiation Proton beam therapy No No Arginine–vasopressin deficiency No Yes No TSH deficiency