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Clinical guidelines for burosumab in the treatment of XLH in children and adolescents: British paediatric and adolescent bone group recommendations

Raja Padidela

Raja Padidela Royal Manchester Children’s Hospital and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Moira S Cheung

Moira S Cheung Evelina London Children’s Hospital, London, UK

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Vrinda Saraff

Vrinda Saraff Birmingham Women’s and Children’s Hospital, Birmingham, UK

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Poonam Dharmaraj

Poonam Dharmaraj Alder Hey Children’s NHS Foundation Trust, Liverpool, UK

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variant in the PHEX gene, as a result of which serum FGF23 levels are elevated, resulting in hypophosphataemia. Low serum phosphate reduces hydroxyapatite formation causing osteomalacia and leads to the failure of apoptosis of hypertrophied