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Kjersti S Bakken
Kjersti S Bakken
Women’s Clinic, Innlandet Hospital Trust, Lillehammer, Norway
Center for International Health, University of Bergen, Bergen, Norway
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Center for International Health, University of Bergen, Bergen, Norway
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Kristina Randjelovic Nermo
Kristina Randjelovic Nermo
Center for International Health, University of Bergen, Bergen, Norway
Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norway
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Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norway
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Bjørn Gunnar Nedrebø
Bjørn Gunnar Nedrebø
Department of Medicine, Haugesund Hospital, Haugesund, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Tim I M Korevaar
Tim I M Korevaar
Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands
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Tor A Strand
Tor A Strand
Center for International Health, University of Bergen, Bergen, Norway
Department of Research, Innlandet Hospital Trust, Lillehammer, Norway
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Department of Research, Innlandet Hospital Trust, Lillehammer, Norway
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criteria and indications for antithyroid drug treatments for Graves’ hyperthyroidism have remained essentially unchanged. A Norwegian government report from 1999 raised concerns regarding thyroid function in pregnancy and highlighted the need for data on
Caiyan Mo
Caiyan Mo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Tao Tong
Tao Tong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ying Guo
Ying Guo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Zheng Li
Zheng Li
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Liyong Zhong
Liyong Zhong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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.34 ATD, TSS 1.91 582 2.53 90.18 0.077 6.57 9.53 − ATD, antithyroid drugs; BMI, body mass index; Dmax, maximum diameter; F, female; FT3, free triiodothyronine; FT4, free thyroxine;GH, growth hormone; IGF-1, insulin-like growth
Xiaowen Zhang
Xiaowen Zhang
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Chen Han
Chen Han
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Hongwei Wang
Hongwei Wang
State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
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Xinghong Sun
Xinghong Sun
Department of Ophthalmology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xin Dou
Xin Dou
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xueying He
Xueying He
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Di Wu
Di Wu
Department of Radiology, Southeast University Medical School Affiliated Zhongda Hospital, Nanjing, China
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Shanmei Shen
Shanmei Shen
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Dalong Zhu
Dalong Zhu
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Xinlin Zhang
Xinlin Zhang
Department of Cardiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Yan Bi
Yan Bi
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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indicator of systemic inflammation. NLR has been reported to be associated with clinical prognosis in multiple disease contexts, including thyroid diseases ( 8 , 9 ). NLR predicts relapse in GD patients following antithyroid drug therapy ( 10 ) and disease
Danzhou Fang
Danzhou Fang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shiying Li
Shiying Li
Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Changgu Zhou
Changgu Zhou
Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Yirui Wang
Yirui Wang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Gengbiao Yuan
Gengbiao Yuan
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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HuiHui Zhang
HuiHui Zhang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Maohua Rao
Maohua Rao
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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. Contemporary hyperthyroidism treatments encompass thyroidectomy, antithyroid drugs, and radioactive iodine ( 131 I) therapy ( 7 ). However, for those with hyperthyroidism and concomitant liver failure, surgery may not be feasible due to the requirement of near
Yuegui Wang
Yuegui Wang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Liwei Hong
Liwei Hong
Department of Nuclear Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Caiyun Yang
Caiyun Yang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
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School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
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Guorong Lv
Guorong Lv
School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
Quanzhou Medical College, Quanzhou, Fujian, China
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Quanzhou Medical College, Quanzhou, Fujian, China
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Kangjian Wang
Kangjian Wang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Xuepeng Huang
Xuepeng Huang
Department of Nuclear Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Haolin Shen
Haolin Shen
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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orbitopathy ( 5 ). Therapies for GD include antithyroid drugs (ATDs), thyroidectomy, or radioactive iodine (RAI) therapy. ATD has only a 50% success rate for most patients after 1 year of treatment, and it may cause side effects such as agranulocytosis
Lian Duan
Lian Duan
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han-Yu Zhang
Han-Yu Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Min Lv
Min Lv
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han Zhang
Han Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Yao Chen
Yao Chen
Changzhi Medical College, Changzhi, Shanxi, China
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Ting Wang
Ting Wang
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Li
Yan Li
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Wu
Yan Wu
Department of Clinical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
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Junfeng Li
Junfeng Li
Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Kefeng Li
Kefeng Li
School of Medicine, University of California, San Diego, California, USA
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per 100,000 individuals per year ( 3 , 4 ). Current treatment for GD patients includes antithyroid drugs (ATDs), radioiodine therapy ( 131 I therapy) (RAI), and thyroidectomy ( 5 ). ATDs tend to have a higher failure rate. In addition, approximately
Qian Yang
Qian Yang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Wencai Ke
Wencai Ke
Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China
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Fanfan Pan
Fanfan Pan
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Xinmei Huang
Xinmei Huang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Bingbing Zha
Bingbing Zha
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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step in thyroid hormone synthesis. Methimazole (MMI) is an established first-line therapy for GD in China and MMI-induced granulocytosis is dose-dependent ( 4 ). Antithyroid drug (ATD)-associated agranulocytosis is a rare but life-threatening event
Waleed K W Al-Badri
Waleed K W Al-Badri
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Hinke Marijke Jellema
Hinke Marijke Jellema
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Arnaud R G G Potvin
Arnaud R G G Potvin
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Ruth M A van Nispen
Ruth M A van Nispen
Amsterdam University Medical Center, Vrije Universiteit, Department of Ophthalmology, Amsterdam Public Health research institute, Amsterdam, the Netherlands
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Peter H Bisschop
Peter H Bisschop
Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Peerooz Saeed
Peerooz Saeed
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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. ( https://doi.org/10.4103/1119-3077.100620 ) 44 Fukao A Takamatsu J Kubota S Miyauchi A & Hanafusa T . The thyroid function of Graves’ disease patients is aggravated by depressive personality during antithyroid drug treatment
Ayse Nurcan Cebeci
Ayse Nurcan Cebeci
Paediatric Endocrinology, Department of Friedrich-Alexander University Hospital, Erlangen, Germany
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Vera Schempp
Vera Schempp
Paediatric Endocrinology, University Hospital, Bonn, Germany
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Katharina Förtsch
Katharina Förtsch
Paediatric Endocrinology, University Hospital, Düsseldorf, Germany
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Bettina Gohlke
Bettina Gohlke
Paediatric Endocrinology, University Hospital, Bonn, Germany
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Michaela Marx
Michaela Marx
Paediatric Endocrinology, Department of Friedrich-Alexander University Hospital, Erlangen, Germany
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Helmuth-Guenther Dörr
Helmuth-Guenther Dörr
Paediatric Endocrinology, Department of Friedrich-Alexander University Hospital, Erlangen, Germany
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Joachim Woelfle
Joachim Woelfle
Paediatric Endocrinology, Department of Friedrich-Alexander University Hospital, Erlangen, Germany
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, antithyroid drug; BR, block and replace; C, carbimazole; D, dose titration; f, female; m, male; LT4, levothyroxine; M, methimazole. The clinical characteristics of children with GD and DS in comparison with GD children without DS are shown in Tables
Heleen I Jansen
Heleen I Jansen
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Marijn M Bult
Marijn M Bult
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Peter H Bisschop
Peter H Bisschop
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Annemieke C Heijboer
Annemieke C Heijboer
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Jacquelien J Hillebrand
Jacquelien J Hillebrand
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
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, however, not investigate the use of other drugs, such as antithyroid drugs, beta-blockers, or glucocorticoids which could have influenced fT4 results as well and should ideally be looked at in future (prospective) studies ( 11 ). We found that an fT4
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