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). The present study investigates the effect of high TSH levels on insulin signal transduction in adipose tissue, and the role of ER stress in this process. We found that TSH can induce insulin resistance in adipose tissue, and the mechanism through which
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). Excess adipose tissue produces various cytokines and inflammatory markers, such as IL-1, IL-6, TNF-α, and leptin. These substances mediate immune and inflammatory responses ( 25 ), with leptin considered to mediate immune responses by shifting helper T
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Department of Endocrinology, The Affiliated Hospital of Guilin Medical University, Guilin, China
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). Subcutaneous fat thickness (SFT) was measured as the distance between the dermis–adipose tissue interface and the muscle–adipose tissue interface ( 32 ). MT was defined as the distance between the deep and superficial aponeuroses in transverse images ( 33 ). PA
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A1; SRB1, scavenger receptor b1; FGF19/21, fibroblast growth factors 19/21; HMG-COA, 3-hydroxy-3-methyl glutaryl coenzyme A; ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; CPT1A, carnitine palmitoyltransferase Iα; WAT, white adipose tissue
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assess body weight excess and adipose tissue overload being linearly associated with a greater risk of thyroid cancer ( 54 ). The risk seems to be affected by gender, with women being exposed to a greater risk of differentiated thyroid cancer than men are
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clear adipose tissue hyperplasia ( 13 ). This further confirms that the lacrimal gland is the target organ associated with symptoms in GO patients and indicates that evaluating the lacrimal gland inflammation may be of clinical relevance. At present
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proportion of adipose tissue in parathyroid hyperplastic lesions was notably higher in the FN MIBI scan group than in the TP group, although not statistically significant ( P = 0.15). Elevated levels of Bcl-2 expression were observed in the TP group compared