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gains in BMI and waist circumference ( 13 ). The need for glucocorticoids in the tissues is regulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) isozymes. Cortisol is generated from inert cortisone by 11β-HSD type 1 in the liver and adipose tissue
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distribution of adipose tissue. In obese males, the pattern differs as leptin levels increase and may be responsible in part for the suppression of the HPG axis. An alternative explanation suggests that it is perhaps the increased aromatase activity of the
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Eder M Csapo B Wadsack C Haas J Catalano PM Desoye G & van Poppel MN . Sex differences in the association of cord blood insulin with subcutaneous adipose tissue in neonates . International Journal of Obesity 2016 40 538 – 542 . ( https