Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Geriatrics, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction The regulation of subcutaneous adipose tissue blood flow (ATBF) is crucial in lipid homeostasis ( 1 , 2 ). It has long been recognized that the ATBF is tightly coupled to adipose tissue metabolism ( 3 , 4 , 5 , 6 ). In
Division of Exercise Science and Sport Medicine, Department of Human Biology, University of Cape Town, 3 Floor Sports Science Institute of South Africa Cape Town, South Africa
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comprises both visceral (VAT) and subcutaneous adipose tissue (SAT), is commonly associated with increased cardiometabolic risk, whereas lower-body gluteo-femoral fat accumulation may be protective ( 4 , 5 ). Within adipose tissue, aromatase ( CYP19A1
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systemic chemerin and insulin resistance has been reported ( 11 , 12 , 15 , 16 ); however, not all studies confirm this relationship ( 17 , 18 ). Furthermore, data regarding the correlations between adipose tissue (AT) chemerin expression and insulin
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complications ( 1 ). Adipose tissue (AT) function and the balance between lipid storage and mobilization play an important role in regulating insulin action. Inability of AT to store fat leads to free fatty acids (FFA) overflow to other tissues and to insulin
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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with T2DM suffer from obesity ( 3 , 4 ). Overloaded energy intake and physical inactivity result in obesity characterized by rapid expansion of adipose tissue. As obesity progresses, adipose expansion outpaces the growth of vasculature, leading to
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Biomedicine, Aarhus University, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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insulin-independent lowering of plasma glucose has several pleiotropic consequences that may contribute to overall cardioprotection ( 2 ). This includes a 2–2.5 kg weight loss and a significant impact on adipose tissue with an increase in lipid
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health, is increasing worldwide. Hence, exploring the mechanisms through which obesity occurs and finding effective prevention and treatment strategies are urgently required in the field of public health. Mammalian adipose tissue comprises white (WAT
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specialized brown adipose tissue (BAT) is the main thermogenic organ, providing a more long-lasting and sustainable source of converting stored energy into heat via non-shivering thermogenesis ( 2 ). Thus, BAT constitutes a potential anti-obesity drug target
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(adiponectin, IL-10) ( 4 ). Chronic inflammation in obese adipose tissues is characterized by a substantial infiltration of macrophages ( 5 ). In the context of prolonged positive energy homeostasis, adipose tissue undergoes expansion to accommodate increased
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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Introduction Mammalian hearts release natriuretic hormones that regulate renal natriuresis and intravascular fluid homeostasis (1, 2) . More recently, an effect on adipose tissue has also been established in which hormone binding to the