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, inhibits lipid synthesis, and reduces blood lipids. ADI is an endogenous bioactive polypeptide secreted by adipocytes that has attracted much attention because of its protective effect against cardiovascular and metabolic diseases ( 35 ). In vitro
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
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1α-hydroxylase) were expressed in human adipocytes, suggesting vitamin D modulates adipose tissue biology ( 30 , 31 ). Vitamin D upregulates the expression of genes involved in fatty acid oxidation and mitochondrial biogenesis in adipose tissue ( 32