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after HFD than wild-type mice on an HFD. It is noteworthy that adipocytes also have been reported to express DKK1 ( 21 , 22 ). Moreover, treatment of pre-adipocytes with Dkk1 suppresses their differentiation in cell cultures ( 23 ). Given that obesity
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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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, mesenchymal stem cells are also the precursor of marrow adipocytes, and the differentiation of these stem cells to these two cell lineages is competitive and reciprocally regulated ( 5 ). Bone marrow adiposity (BMA) itself is increasingly recognised to have a
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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by inducing the browning of s.c. white adipocytes, which are metabolically favourable for burning energy through thermogenesis ( 51 ). Depending on the experimental conditions (i.e. thermoneutral or cold), brown adipose tissue activity has been