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Department of Medicine, University of Padova, Padova, Italy
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suggesting that low INSL3 levels might play a role in sarcopenia in hypogonadal patients. Furthermore, the identification of VDR in skeletal muscle cells provided evidence of the role of vitamin D in skeletal muscle ( 97 , 98 ). A severe reduction in
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) . After its release to tissues, 1,25(OH) 2 D acts on the vitamin D receptor (VDR), which is present in most tissues, and exerts numerous actions throughout the body ( 9 ). The major changes in vitamin D metabolism during pregnancy are mostly associated