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The role of menin in bone pathology

Anna Gorbacheva

Anna Gorbacheva Endocrinology Research Center, Moscow, Russian Federation

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Anna Eremkina

Anna Eremkina Endocrinology Research Center, Moscow, Russian Federation

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Daria Goliusova

Daria Goliusova Endocrinology Research Center, Moscow, Russian Federation

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Julia Krupinova

Julia Krupinova Endocrinology Research Center, Moscow, Russian Federation

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Natalia Mokrysheva

Natalia Mokrysheva Endocrinology Research Center, Moscow, Russian Federation

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, apparently due to the effect on osteoprotegerin ( 70 ). Therefore, it can be argued that MEN1 mutations may lead to increased osteoclastogenic activity through PPARγ inhibition. WT menin also directly promotes the transcription of vitamin D receptor (VDR