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Clinical guidelines for burosumab in the treatment of XLH in children and adolescents: British paediatric and adolescent bone group recommendations

Raja Padidela

Raja Padidela Royal Manchester Children’s Hospital and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Moira S Cheung

Moira S Cheung Evelina London Children’s Hospital, London, UK

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Vrinda Saraff

Vrinda Saraff Birmingham Women’s and Children’s Hospital, Birmingham, UK

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Poonam Dharmaraj

Poonam Dharmaraj Alder Hey Children’s NHS Foundation Trust, Liverpool, UK

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left untreated, tertiary hyperparathyroidism. Active vitamin D analogues can prevent hyperparathyroidism but increase the risk of nephrocalcinosis. Burosumab is a recombinant human IgG1 MAB that binds to and inhibits the activity of fibroblast growth