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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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these bone characteristics may explain the increased fracture risk observed in this population ( 7 ). Various endocrine and metabolic disturbances, including hypothyroidism ( 8 ), hypogonadism ( 1 , 9 , 10 ), hypercortisolism ( 2 , 11 ) and IGF-1
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process. Initially, osteoprogenitor cells differentiate into OB as a consequence of molecular stimuli such as IGF1 and 2, the canonical Wnt/b-catenin pathway, Wnt10b, TGFb and/or BMP2/4/7 that modulate the expression of key osteogenic genes such as RUNX2
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studies mostly considered the following potential confounders: age, sex, season of blood sampling, smoking, vitamin D status, body fat mess, weight, height, BMI, IGF-1, PTH, UVB, alcohol, tobacco, sports, use of multivitamin supplements, menopausal status