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Rachel Forfar Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Mashal Hussain Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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Dillon Popat Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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Li F Chan Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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through five known melanocortin receptors (MC1R–MC5R) of the class A seven transmembrane G-protein-coupled receptor family (GPCR) which, when activated, stimulate the production of intracellular cAMP ( 1 ). ACTH is the only endogenous agonist for MC2R

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