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of autoimmune diseases by suppressing effector T cells and B cells ( 6 ). The immunosuppressive mechanisms employed by Tregs include the expression of cytotoxic T-lymphocyte antigen-4 (CTLA-4) to suppress costimulation, consumption of interleukin-2
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. ( https://doi.org/10.1210/clinem/dgaa157 ) 18 Georgia A Asnis MCC Febres G Tsang A Bessler M Korner J . Roux-en-Y gastric bypass is associated with hyperinsulinemia but not increased maximal B-cell function . Journal of the Endocrine
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). The relative ratios of p-AMPK to total AMPKα were plotted based on quantitative densitometric analysis (B). Cells were exposed to 0.5 mM PA or OA for 48 h with AICAR or dynasore; confocal images of MIN6 cells stained with Alexa-488-conjugated donkey
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( n = 127) To analyze C-peptide levels and its trajectory throughout pregnancy in maternal serum and cord blood, to examine the hypothesis of B-cell regeneration in pregnant women with T1DM First maternal C-peptide appearance at 34 weeks was