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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Université Libre de Bruxelles, Bruxelles, Belgium
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School of Medicine, Zagreb, Croatia
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Department of Clinical Nutrition, Landspitali-National University Hospital, Reykjavik, Iceland
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Goldman School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Universitat Autònoma de Barcelona, Barcelona, Spain
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Frölunda Specialist Hospital, Västra Frölunda, Sweden
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Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg Centre of Molecular and Translational Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Objective
Registers of diagnoses and treatments exist in different forms in the European countries and are potential sources to answer important research questions. Prevalence and incidence of thyroid diseases are highly dependent on iodine intake and, thus, iodine deficiency disease prevention programs. We aimed to collect European register data on thyroid outcomes to compare the rates between countries/regions with different iodine status and prevention programs.
Design
Register-based cross-sectional study.
Methods
National register data on thyroid diagnoses and treatments were requested from 23 European countries/regions. The provided data were critically assessed for suitability for comparison between countries/regions. Sex- and age-standardized rates were calculated.
Results
Register data on ≥1 thyroid diagnoses or treatments were available from 22 countries/regions. After critical assessment, data on medication, surgery, and cancer were found suitable for comparison between 9, 10, and 13 countries/regions, respectively. Higher rates of antithyroid medication and thyroid surgery for benign disease and lower rates of thyroid hormone therapy were found for countries with iodine insufficiency before approx. 2001, and no relationship was observed with recent iodine intake or prevention programs.
Conclusions
The collation of register data on thyroid outcomes from European countries is impeded by a high degree of heterogeneity in the availability and quality of data between countries. Nevertheless, a relationship between historic iodine intake and rates of treatments for hyper- and hypothyroid disorders is indicated. This study illustrates both the challenges and the potential for the application of register data of thyroid outcomes across Europe.
Department of Hematology, University of Groningen, University Medical Center Groningen, The Netherlands
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disorders (defined as present when they were affirmatively answered and as being absent when answered negatively or missing), medication list, physical examination, biochemical measurements and MINI were collectively used to determine the presence of disease
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decreased values for fT3 in peripheral tissue. To answer this question, we compared the levels of fT3, fT4, TSH and the fT3/fT4 ratio of children with cH under LT4 treatment and healthy children. Here, we found significantly lower fT3/ fT4 ratios in
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Endocrinology Service, Instituto Nacional de Câncer, Rio de Janeiro, Brazil
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non-thyroidal findings on SPECT-CT. This was defined as any finding reported by the radiologist in his/her impression that was not thyroid or thyroid cancer-related. From this, we sought answers to three principal study questions: Did SPECT-CT improve
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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the position to obtain clinical data in sufficient numbers to conduct conclusive studies. The European ped-DTC registry is a cooperative effort that will provide large enough clinical datasets to answer questions conclusively by conducting well
Medical College, Shantou University, Shantou, China
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Medical College, Shantou University, Shantou, China
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& Rocco M . Nonthyroidal illness syndrome: to treat or not to treat? Have We Answered the Question? A Review of Metanalyses . Frontiers in Endocrinology 2022 13 850328. ( https://doi.org/10.3389/fendo.2022.850328 ) 5 Wang B Liu S Li L Yao Q
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EW . Artificial intelligence in medical practice: the question to the answer? American Journal of Medicine 2018 131 129 – 133 . ( https://doi.org/10.1016/j.amjmed.2017.10.035 ) 15 Dimopoulos AC Nikolaidou M Caballero FF Engchuan W Sanchez
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. ( https://doi.org/10.2967/jnumed.120.243170 ) 8 Bartalena L Chiovato L & Vitti P . Management of hyperthyroidism due to Graves’ disease: frequently asked questions and answers (if any) . Journal of Endocrinological Investigation 2016 39 1105
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: 0.26–0.35)), which we could confirm; they stated that this makes it an excellent rule out malignancy. To avoid unnecessary surgery and answer the question, if the patient could be followed up, a rule-out test aimed to predict benign nodules should
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are positively related to TC, LDL-C in patients with morbid obesity and type 2 diabetes ( 131 ), but whether it is related to hypothyroidism or not, the answer remains uncertain. ANGPTL6, also known as AGF, does not bind to angiogenin receptors. In