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Unni Syversen Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway

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Mats Peder Mosti Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway

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Ida Maria Mynarek Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

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Trude Seselie Jahr Vedal Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

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Kristin Aasarød Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Department of Gastroenterology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway

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Trude Basso Department of Orthopedics, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway

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Janne E Reseland Department of Biomaterials, University of Oslo, Oslo, Norway

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Per Medbøe Thorsby Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Aker, Oslo, Norway

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Bjorn O Asvold Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway

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Erik Fink Eriksen Department of Biomaterials, University of Oslo, Oslo, Norway

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Astrid Kamilla Stunes Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway

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osteoporosis and fractures and secondary osteoporosis due to various underlying systemic disorders ( 9 ). Accumulation of advanced glycation end products (AGEs) has been proposed to affect bone quality in subjects with diabetes ( 3 , 10 ). Pentosidine is a

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Chun-feng Lu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Wang-shu Liu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xiao-qin Ge Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Yan Wang Department of Geriatrics, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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expressed in all human tissues. In addition to regulating adenosine concentration by catalyzing the irreversible deamination of adenosine to inosine ( 5 ), ADA is also essential for the differentiation and maturation of T lymphocytes and is a general marker

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Shu-Meng Hu Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yang-Juan Bai Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Ya-Mei Li Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Ye Tao Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Xian-Ding Wang Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Tao Lin Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Lan-Lan Wang Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yun-Ying Shi Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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, serum creatinine (SCr), serum calcium, serum inorganic phosphate, urinary calcium and PTH, as well as bone turnover markers (BTMs), including bone-specific alkaline phosphatase (bALP), N-terminal propeptide of type 1 collagen (P1NP), type I collagen

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Jan Kvasnička 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Ondřej Petrák 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Tomáš Zelinka 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Judita Klímová 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Barbora Kološová 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Květoslav Novák Department of Urology, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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David Michalský 1st Department of Surgery, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Jiří Widimský Jr 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Robert Holaj 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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tumour removal ( 53 ), therefore systemic inflammation may also influence our results. We are aware of the limitations of our study. PHEO is a rare disease, and we are not able to enroll a larger number of patients into the study. Moreover, speckle

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Weiwei He Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China

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Bin Wang Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Kaida Mu Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Jing Zhang Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Yanping Yang Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Wei Yao Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Sheli Li Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China

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Jin-an Zhang Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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AITDs and disease progression ( 7 , 8 ). AITDs mainly have two types of symptoms, Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). HT is the most common thyroid inflammation characterized by abnormally elevated thyroglobulin antibodies (TGAb) and

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Qing Zhu Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Jianbin Su Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Xueqin Wang Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Mengjie Tang Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Yingying Gao Department of Rheumatology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Dongmei Zhang Clinical Medicine Research Center, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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levels of TNF-α in the serum of GD patients may be affect to a systemic response to disease or to an intrathyroidal antigen–antibody reciprocity. Increase of cytokines in the thyroid gland may lead to the production of other cytokines by autoreactive

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Zeting Li Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Ling Pei Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Huangmeng Xiao Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Nan Chen Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Fenghua Lai Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Shufang Yue Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Changliu Xu Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Yanbing Li Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Haipeng Xiao Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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Xiaopei Cao Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China

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inhibit the systemic inflammatory response and regulate the function of pancreatic islets based on this pancreas–inflammation–intestine regulatory axis, which once again clarifies the inseparable relationship between the pancreas, inflammation, and

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C Chiapponi Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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H Alakus Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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M Faust Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University Hospital of Cologne, Cologne, Germany

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A M Schultheis Department of Pathology, University Hospital of Cologne, Cologne, Germany

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J Rosenbrock Department of Radiation Therapy, University Hospital of Cologne, Cologne, Germany

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M Schmidt Department of Nuclear Medicine, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany

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guidelines ( 11 ). In fact, there is currently no adjuvant systemic treatment that can eliminate residual disease and R0 resection is pivotal. For inoperable cases or frequent structural recurrence after repetitive surgery, external beam radiation (EBRT) is

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Elizabeth Yan Zhang Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA

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Bao-Ting Zhu Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA

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) Histological changes in H/E-stained tissue sections. (E) The severity of skin inflammation on the back of mice at 8 days after first sensitization with DNCB. It should be noted that in the data shown in this figure, mice labeled as group ‘E 3 ’ received E 3

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Eva Olga Melin Department of Clinical Sciences, Endocrinology and Diabetes, Lund University, Faculty of Medicine, Lund, Sweden
Department of Research and Development, Region Kronoberg, Växjö, Sweden
Region Kronoberg, Primary Care, Växjö, Sweden

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Jonatan Dereke Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Diabetes Research Laboratory, Lund, Sweden

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Maria Thunander Department of Clinical Sciences, Endocrinology and Diabetes, Lund University, Faculty of Medicine, Lund, Sweden
Department of Research and Development, Region Kronoberg, Växjö, Sweden
Department of Internal Medicine, Endocrinology and Diabetes, Central Hospital, Växjö, Sweden

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Magnus Hillman Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Diabetes Research Laboratory, Lund, Sweden

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activation of the innate immune system causing systemic inflammation ( 2 , 3 , 5 , 6 , 7 ). We have previously shown in these patients with T1D that depression was associated with inadequate glycaemic control ( 8 ), and with high midnight salivary

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