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A H Ludwig-Slomczynska Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland

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S Borys Department of Metabolic Diseases, Jagiellonian University Medical College
University Hospital, Krakow, Poland

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M T Seweryn Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland

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J Hohendorff Department of Metabolic Diseases, Jagiellonian University Medical College
University Hospital, Krakow, Poland

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P Kapusta Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland

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B Kiec-Wilk Department of Metabolic Diseases, Jagiellonian University Medical College
University Hospital, Krakow, Poland

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E Pitera Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland

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P P Wolkow Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland

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M T Malecki Department of Metabolic Diseases, Jagiellonian University Medical College
University Hospital, Krakow, Poland

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diagnosed form of DFS. The yearly incidence rate reported among patients with diabetes has reached 6.0% ( 2 ). It is associated with a high rate of recurrence, amputation, and mortality ( 3 ). The standard management of the DFU includes glycemic control

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Qian Deng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Yue Zhu Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Mengmeng Zhang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Aihua Fei Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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Jiaqi Liang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Jinjin Zheng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Qingping Zhang College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China

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Tong Cheng Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China

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Xia Ge Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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diabetes-related ferroptosis, thus delaying the progression of DN ( 108 , 109 , 110 ). Canagliflozin (Cana) is a new sodium-glucose cotransporter 2 inhibitor (SGLT2i) hypoglycemic drug; it can improve diabetic myocardial structure and function, preserve

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Xuhua Mao Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China

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Hucheng Chen Department of Nuclear Medicine, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China

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Junmin Tang Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China

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Liangliang Wang Department of Neurology, Yixing People’s Hospital Affiliated to Jiangsu University, Yixing, Wuxi, Jiangsu, China

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Tingting Shu Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China

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Introduction Type 2 diabetes arises when the endocrine pancreas fails to secrete sufficient insulin to cope with the metabolic demand because of acquired insulin resistance and β-cell dysfunction ( 1 ). Inhibition of insulin synthesis plays an

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E R Polina Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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F M Oliveira Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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R C Sbruzzi Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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D Crispim Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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L H Canani Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

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K G Santos Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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Introduction Diabetic retinopathy (DR) is a neurodegenerative complication of diabetes ( 1 ) consistently associated with other diabetic complications and with an overall worse prognosis ( 2 ). Hyperglycaemia triggers the activation of

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniela Betea Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-François Bonneville Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Chiara Villa Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Jean-Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Catherine Waeber Stephan Clinique Générale Ste-Anne, Fribourg, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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with AIP mutations have a statistically significantly younger age at onset, larger tumor size, and higher GH secretion ( 9 , 10 ). Importantly, treatment of acromegaly in AIP- mutated patients is more difficult due to this aggressive disease profile

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Panisa Hantrakun Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Rattanaporn Sekararithi Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Thidarat Jaiwongkam Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Sirinart Kumfu Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Chatree Chai-adisaksopha Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Theera Tongsong Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Phudit Jatavan Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Gestational diabetes mellitus (GDM), one of the most common complications in pregnancy, is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy ( 1 ). GDM usually disappears shortly after birth but up to 50% will

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Pernille Bækgaard Udesen The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark
Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anja Elaine Sørensen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Rikke Svendsen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Nanna Louise Skov Nielsen Department of Science and Environment, Roskilde University, Roskilde, Denmark
Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark

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Marie Louise Muff Wissing Aleris Hamlet Hospital Group, The Fertility Clinic, Søborg, Denmark

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Marianne Skovsager Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anne Lis Mikkelsen Englund The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark

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Louise Torp Dalgaard Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Whitehead M Ramírez CM Goedeke L et al . Circulating microRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes . Diabetes 2017 66 347 – 3 57 . ( https://doi.org/10.2337/db16-0731 ) 27899485 24 Ghai V

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Barbara J Boucher The Blizard Institute, Queen Mary University of London, London, UK

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Nutrition 2010 103 549 – 555 . ( https://doi.org/10.1017/S0007114509992017 ) 38 Dawson-Hughes B Nelson J Pittas AG . Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and

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David S McLaren Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK

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Aarani Devi Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK

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Nikolaos Kyriakakis Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK

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Michelle Kwok-Williams Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK

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Robert D Murray Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK
Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK

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( 55 ). Height data were available in 57 patients after a median of 41 months from PBT and showed a decline in median height from the 54th percentile at baseline to the 36th percentile ( 55 ). In a cohort of adult-onset grade 2 glioma, new endocrine

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Tingting Shu Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China

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Zhigang Lv Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China

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Yuchun Xie Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China

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Junming Tang Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China

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Xuhua Mao Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China

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-Real JM McClain D Manco M. Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of Type 2 diabetes . Diabetes Care 2015 38 2169 – 2176 . ( https://doi.org/10.2337/dc14-3082 ) 26494808 10.2337/dc14-3082 7

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