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Bledar Daka, Thord Rosen, Per Anders Jansson, Lennart Råstam, Charlotte A Larsson and Ulf Lindblad

(17) . Serum insulin was analysed using RIA. Insulin resistance was estimated using the homeostatic model assessment for insulin resistance (HOMA-IR) (18) . Total testosterone was analysed according to UniCel DxI 800 Beckman Access Immunoassay System

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Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

.7%), control 2 = 24.5 (6.7%) and control 3 = 49.6 pg/mL (6.8%)) and insulin (control 1 = 100.3 pmol/L (10%), and control 2 = 332.2 pmol/L (9.5%)). Measurement of insulin resistance An index of fasting insulin resistance (HOMA-IR) and postprandial

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

, increased epicardial and pericardial fat is linked with changes in heart function in men suffering from metabolic syndrome ( 28 ), as well as in obese patients suffering from insulin resistance ( 29 ). Of note, MYCL and pericardial fat are two lipid stores

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Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel and André P van Beek

. Furthermore, to gain insight in the mechanisms provoking hypoglycaemia, we performed gut hormone analyses and assessed the beta-cell function and insulin resistance with several indices. Patients and methods Study population Details on the study

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Katica Bajuk Studen and Marija Pfeifer

aim of this article is to explore and review current evidence that associates PCOS with cardiometabolic abnormalities and possibly an increased risk of cardiovascular disease. Insulin resistance, metabolic syndrome, obesity and sleep disturbances

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Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir and Bulent Okan Yildiz

fully understood, obesity, insulin resistance and hyperandrogenemia, which are the main features of PCOS, are all proposed to play a role in the development of OSA in patients with PCOS. The objective of this meta-analysis was to examine if there is an

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Meena Asmar, Ali Asmar, Lene Simonsen, Flemming Dela, Jens Juul Holst and Jens Bülow

glucose disposal ( 27 , 28 ). It recruits microvasculature in the muscle by relaxing terminal arterioles thereby expanding the microvascular blood flow ( 20 , 21 , 29 ). Furthermore, insulin induces relaxation of resistance vessels and causes an

Open access

Alessandra Gambineri and Carla Pelusi

development of T2DM in PCOS ( 17 ). These data support the most widely accepted hypothesis that the increased risk of T2DM in PCOS is mainly related to the strong interaction between androgens, obesity and peripheral insulin resistance. Animal studies

Open access

Julia Modesto Vicente, Junia Carolina Santos-Silva, Caio Jordão Teixeira, Dailson Nogueira de Souza, Jean Franciesco Vettorazzi, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Fabio Takeo Sato, Marco Aurélio Ramirez Vinolo, Everardo Magalhães Carneiro, Silvana Bordin and Gabriel Forato Anhê

infiltrated in adipose fat pads Macrophages infiltrated in distinct adipose fat pads are recognized to produce several interleukins that are able to cause insulin resistance ( 17 ). Adipose tissue macrophages (ATM) can assume two distinct phenotypes, the M1

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Chunliang Yang, Junyi Li, Fei Sun, Haifeng Zhou, Jia Yang and Chao Yang

gluconeogenesis. Specifically, in the long run, metabolic disorders that are responsible for insulin resistance may also, in turn, damage the insulin-secreting capability of islet β cells through the accumulation of proinflammatory cytokines and toxic lipids ( 1