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%. It can help refine the assessment of thyroid nodules with an indeterminate cytology ( 39 , 40 , 41 , 42 , 43 ). Furthermore, multiple studies provided evidence of the prognostic value that the assessment of TERT mutations, either alone or, most
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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body composition described in endometriosis and polycystic ovary syndrome (PCOS) ( 15 ) as well as in hyperthyroidism and hypothyroidism. Dash (–) indicates that evidence is missing or inconclusive. Endometriosis PCOS Hyperthyroidism
MRC Epidemiology Unit, Department of Epidemiology and Department of Internal Medicine, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Post Box 285, Cambridge CB2 0QQ, UK
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therapeutic intervention (2, 3) . Targeted intervention at the biomarker level would be useful where there is evidence for a causal relationship between an exposure (like a biomarker) and T2D (4) . Traditional epidemiological studies lack sufficient
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Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
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and summarise the major scientific developments on the topic of human infertility associated with ED exposure, integrating evidence from epidemiological and experimental studies. Examples of well-known and hypothetical ED are selected to highlight the
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of thyroiditis among women with PCOS. The results suggested a higher incidence of thyroiditis in PCOS than those in controls ( 31 ). Therefore, the aim of this systematic review and meta-analysis was to summarize and update the available evidence
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features of hypercortisolism and evidence of pituitary origin of hypercortisolism based on some or all of the following tests: inappropriate-normal or elevated ACTH, abnormal dexamethasone suppression test, adequate stimulation with a corticotropin
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multiple myeloma with marked elevation of serum calcium, evidence that a humoral component can also contribute to the skeletal complications and hypercalcemia in myeloma ( 31 ). Of note, patients with normocalcemic states have been found to have tumors
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treatment for hyperprolactinemia. In case the findings from this systematic review could be replicated in studies of a higher evidence level, the clinical implications are potentially large. Conclusion This systematic review suggests a reduction of
INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
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using a meta-analytic approach. Overall, there is no evidence of beneficial effects of intensive glycaemic control on cognitive decline. A beneficial effect was observed in only one trial targeting elderly persons with well-controlled type 2 diabetes
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role of IGF1 in the management of patients with delayed puberty or hypogonadotropic hypogonadism. It is concerning that the evidence in humans is scarce, as the IGF1R knockout is incompatible with life. The human phenotype that is closest to the animal
