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Sara Ahmadi Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Iñigo Landa Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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%. It can help refine the assessment of thyroid nodules with an indeterminate cytology ( 39 , 40 , 41 , 42 , 43 ). Furthermore, multiple studies provided evidence of the prognostic value that the assessment of TERT mutations, either alone or, most

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Signe Kirkegaard Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Nanna Maria Uldall Torp Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

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Stine Linding Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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body composition described in endometriosis and polycystic ovary syndrome (PCOS) ( 15 ) as well as in hyperthyroidism and hypothyroidism. Dash (–) indicates that evidence is missing or inconclusive. Endometriosis PCOS Hyperthyroidism

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Ali Abbasi MRC Epidemiology Unit, Department of Epidemiology and Department of Internal Medicine, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Post Box 285, Cambridge CB2 0QQ, UK
MRC Epidemiology Unit, Department of Epidemiology and Department of Internal Medicine, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Post Box 285, Cambridge CB2 0QQ, UK

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therapeutic intervention (2, 3) . Targeted intervention at the biomarker level would be useful where there is evidence for a causal relationship between an exposure (like a biomarker) and T2D (4) . Traditional epidemiological studies lack sufficient

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André Marques-Pinto Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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Davide Carvalho Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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and summarise the major scientific developments on the topic of human infertility associated with ED exposure, integrating evidence from epidemiological and experimental studies. Examples of well-known and hypothetical ED are selected to highlight the

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Mírian Romitti Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Vitor C Fabris Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Patricia K Ziegelmann Postgraduate Program in Epidemiology and Department of Statistics, Institute of Mathematics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Poli Mara Spritzer Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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of thyroiditis among women with PCOS. The results suggested a higher incidence of thyroiditis in PCOS than those in controls ( 31 ). Therefore, the aim of this systematic review and meta-analysis was to summarize and update the available evidence

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Nadine M Vaninetti Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada

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David B Clarke Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada

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Deborah A Zwicker Cape Breton Regional Hospital, Sydney, Nova Scotia, Canada

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Churn-Ern Yip Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada

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Barna Tugwell Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada

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Steve Doucette Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

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Chris Theriault Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

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Khaled Aldahmani Department of Medicine, Tawam Hospital in Affiliation with Johns Hopkins, AI Ain, UAE

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Syed Ali Imran Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada

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features of hypercortisolism and evidence of pituitary origin of hypercortisolism based on some or all of the following tests: inappropriate-normal or elevated ACTH, abnormal dexamethasone suppression test, adequate stimulation with a corticotropin

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Sondra O’Callaghan Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA

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Hanford Yau Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA

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multiple myeloma with marked elevation of serum calcium, evidence that a humoral component can also contribute to the skeletal complications and hypercalcemia in myeloma ( 31 ). Of note, patients with normocalcemic states have been found to have tumors

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Sarah Byberg Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Jesper Futtrup Panum Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Mikkel Andreassen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Jesper Krogh Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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treatment for hyperprolactinemia. In case the findings from this systematic review could be replicated in studies of a higher evidence level, the clinical implications are potentially large. Conclusion This systematic review suggests a reduction of

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Richard H Tuligenga INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France

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using a meta-analytic approach. Overall, there is no evidence of beneficial effects of intensive glycaemic control on cognitive decline. A beneficial effect was observed in only one trial targeting elderly persons with well-controlled type 2 diabetes

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Rossella Cannarella Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Andrea Crafa Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Sandro La Vignera Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Rosita A Condorelli Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Aldo E Calogero Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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role of IGF1 in the management of patients with delayed puberty or hypogonadotropic hypogonadism. It is concerning that the evidence in humans is scarce, as the IGF1R knockout is incompatible with life. The human phenotype that is closest to the animal

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