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Ana P Estrada-Flórez Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia

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Mabel E Bohórquez Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Alejandro Vélez Dinamica IPS, Medellín, Antioquia, Colombia
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Carlos S Duque Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Jorge H Donado Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Gilbert Mateus Hospital Federico Lleras Acosta, Ibagué, Tolima, Colombia

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Cesar Panqueba-Tarazona Universidad Surcolombiana, Neiva, Huila, Colombia

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Guadalupe Polanco-Echeverry Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Ruta Sahasrabudhe Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Magdalena Echeverry Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Luis G Carvajal-Carmona Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia

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the United States by demographic and tumor characteristics, 1980–2005 . Cancer Epidemiology, Biomarkers and Prevention 2009 784 – 791 . ( https://doi.org/10.1158/1055-9965.EPI-08-0960 ) 34 Pellegriti G Frasca F Regalbuto C Squatrito S

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Lisette van Alewijk Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands

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Kirsten Davidse Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands

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Karlijn Pellikaan Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands

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Judith van Eck Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, the Netherlands

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Anita C S Hokken-Koelega Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, the Netherlands
Academic Centre for Growth, Erasmus University Medical Centre, Rotterdam, the Netherlands
Dutch Growth Research Foundation, Rotterdam, the Netherlands

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Theo C J Sas Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, the Netherlands
Diabeter, National Diabetes Care and Research Centre, Rotterdam, the Netherlands

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Sabine Hannema Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, the Netherlands
Department of Paediatric Endocrinology, Leiden University Medical Centre, Leiden, the Netherlands

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Aart J van der Lely Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands

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Laura C G de Graaff Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands
Academic Centre for Growth, Erasmus University Medical Centre, Rotterdam, the Netherlands

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-011-9640-9 ) 37 Merke D Kabbani M Congenital adrenal hyperplasia: epidemiology, management and practical drug treatment . Paediatric Drugs 2001 3 599 – 611 . ( https://doi.org/10.2165/00128072-200103080-00005 ) 38 Betterle C Presotto F Furmaniak

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Dorte Glintborg Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Katrine Hass Rubin Open Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark

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Simon Bang Mohr Kristensen Open Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark

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Øjvind Lidegaard Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Guy T’Sjoen Department of Endocrinology and Center for Sexology and Gender, Ghent University Hospital, Gent, Belgium

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Aisa Burgwal Department of Endocrinology and Center for Sexology and Gender, Ghent University Hospital, Gent, Belgium

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Malene Hilden Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Centre for Gender Identity, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Marianne Skovsager Andersen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Sandegaard JL Ehrenstein V Pedersen L Sorensen HT . The Danish National Patient Registry. The Danish National Patient Registry: a review of content, data quality, and research potential . Clinical Epidemiology 2015 7 449 – 490 . ( https://doi.org/10

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Jes Sloth Mathiesen Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Jens Peter Kroustrup Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Kirstine Stochholm Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Center for Rare Diseases, Aarhus University Hospital, Aarhus N, Denmark

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Per Løgstrup Poulsen Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Sten Schytte Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Stefano Christian Londero Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Henrik Baymler Pedersen Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark

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Christoffer Holst Hahn Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark

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Bjarki Ditlev Djurhuus Department of ORL Head & Neck Surgery, Zealand University Hospital, Køge, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Herlev, Denmark

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Sören Möller Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark

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Mette Gaustadnes Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Maria Rossing Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Finn Cilius Nielsen Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Kim Brixen Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Anja Lisbeth Frederiksen Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

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Christian Godballe Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark

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the Danish Thyroid Cancer Group (DATHYRCA)
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including populations from Brazil, the USA, the Netherlands, Italy and France also failed to detect a significant change during roughly comparable periods ( 38 , 42 , 43 , 44 , 45 ). However, two recent USA studies based on Surveillance, Epidemiology

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Lukas Ochsner Ridder Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Agnethe Berglund Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

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Kirstine Stochholm Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark

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Simon Chang Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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Claus H Gravholt Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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recent years, especially concerning the natural course during adulthood. Knowledge concerning 47,XYY syndrome is much more limited. Here, we review the similarities and differences between KS and XYY. Diagnosis and epidemiology of male supernumerary

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Fabian Eichelmann Department of Epidemiology, Nutrition, Immunity and Metabolism Start-up Lab, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

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Cornelia Weikert Department of Food Safety, Federal Institute for Risk Assessment
Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany

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Romina di Giuseppe Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany

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Ronald Biemann Department for Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany

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Berend Isermann Department for Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany

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Matthias B Schulze Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
German Center of Diabetes Research (DZD), München-Neuherberg, Germany

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Heiner Boeing Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

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Krasimira Aleksandrova Department of Epidemiology, Nutrition, Immunity and Metabolism Start-up Lab, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

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Ioannidis JPA Kirsch-Volders M Matullo G Phillips DH Schoket B Stromberg U STrengthening the Reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement . PLoS Medicine

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Andrea Mazurat Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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Andrea Torroni Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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Jane Hendrickson-Rebizant Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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Harbinder Benning Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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Richard W Nason Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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K Alok Pathak Section of Surgical Oncology, Department of Surgery, CancerCare Manitoba, University of Manitoba, GF440 A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9

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. Acknowledgements The authors acknowledge the assistance provided by staff of Department of Epidemiology and Medical Records (CancerCare Manitoba and Health Sciences Centre) and Manitoba Cancer Registry. References 1 Nixon IJ Ganly I Patel S Palmer FL

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Xi Zhang Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China

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Xiurong Shen Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China

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Wan Zhou Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Mengyun Xu Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Yan Xing Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Jianping Weng Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Shandong Ye Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Suowen Xu Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Zhi Zhang Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Wei Wang Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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urine albumin/urine creatinine. Fasting C-peptide (FCP) was assayed by electrochemiluminescence immunoassay (Roche Diagnostics GmbH). The estimated glomerular filtration rate was calculated by the Chronic Kidney Disease Epidemiology Collaboration

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Lijuan Fu Department of Laboratory, Changyi People’s Hospital of Shandong Province, Changyi, Shandong, China

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Jinhuan Ma Department of Laboratory, Changyi Maternal and Child Health Hospital of Shandong Province, Changyi, Shandong, China

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Sumei Yan Department of Obstetrics, Changyi Maternal and Child Health Hospital of Shandong Province, Changyi, Shandong, China

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Qijun Si Department of Laboratory, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang, China

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manuscript as submitted. References 1 Aspray TJ Hill TR . Osteoporosis and the ageing skeleton . Sub-Cellular Biochemistry 2019 91 453 – 476 . ( https://doi.org/10.1007/978-981-13-3681-2_16 ) 2 Lane NE . Epidemiology, etiology, and

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Wang Chengji College of Physical Education, Chaohu University, Anhui Province, China

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Fan Xianjin College of Physical Education, Chaohu University, Anhui Province, China

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2007 15 1875 – 1885 . ( https://doi.org/10.1038/oby.2007.222 ) 10.1038/oby.2007.222 4 Meigs JB. Epidemiology of the insulin resistance syndrome . Current Diabetes Reports 2003 3 73 – 79 . ( https://doi.org/10.1007/s11892

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