Search Results

You are looking at 81 - 90 of 547 items for :

  • development x
Clear All
Open access

Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani and Kristina Schaedlich

influence during early development (i.e. preconceptional up to 1000 days of postnatal life) can program the unborn/newborn for metabolic dysfunctions later in life. Apart from environmental factors maternal diseases such as overweight or excessive weight

Open access

Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer and Irvin M Modlin

with reproducibility and accurate delineation of metastatic disease, particularly extra-liver disease. The development of new lesions is probably the most powerful indicator of disease progression. Functional imaging with somatostatin receptor

Open access

Xuan Luo, Tingting Zheng, Chaoming Mao, Xin Dong, Xiao Mou, Chengcheng Xu, Qingyan Lu, Baocui Liu, Shengjun Wang and Yichuan Xiao

. Importantly, IL-1β was also highly expressed in the tissues of the HT patients, suggesting that there is an interaction between MRP14 and IL-1β in the development of HT. Notably, our results showed that IL-1β induced the expression of not only chemokines in

Open access

Juan Carlos Juárez-Cruz, Miriam Daniela Zuñiga-Eulogio, Monserrat Olea-Flores, Eduardo Castañeda-Saucedo, Miguel Ángel Mendoza-Catalán, Carlos Ortuño-Pineda, Ma Elena Moreno-Godínez, Sócrates Villegas-Comonfort, Teresita Padilla-Benavides and Napoleón Navarro-Tito

, which further enhances the predisposition of developing breast tumors ( 4 ). Among these molecules, leptin is one of the most important adipokines involved in the development and progression of mammary tumors ( 5 ). Leptin is a hormone with a molecular

Open access

Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing and Krasimira Aleksandrova

-scale prospective population-based studies exist to support or refute generated hypothesis on chemerin involvement in disease development. Important prerequisite for planning biomarker assessment in a prospective study is the assessment of whether single biomarker

Open access

Selina Mäkinen, Yen H Nguyen, Paulina Skrobuk and Heikki A Koistinen

to ROS production ( 18 ), we next analysed if development of insulin resistance of glucose uptake is related to ROS. Human myotubes were exposed for 12 h to palmitate, oleate or their combination. Mitochondrial ROS production was significantly

Open access

K L Gatford, G K Heinemann, S D Thompson, J V Zhang, S Buckberry, J A Owens, G A Dekker, C T Roberts and on behalf of the SCOPE Consortium

Introduction The insulin-like growth factors (IGFs), IGF1 and IGF2, are important regulators of placental and foetal development, as well as postnatal growth and metabolism. In humans, circulating IGF1 peaks in adolescence and then falls with age

Open access

B Shahida, P Sahlstrand Johnson, R Jain, H Brorson, P Åsman, M Lantz and T Planck

Introduction Autoimmune thyroid disease is a prerequisite for the development of Graves’ ophthalmopathy (GO), and both thyroid and orbital tissues are infiltrated by immunocompetent cells. The thyroid-stimulating hormone receptor (TSHR) acts

Open access

Stefano Mangiola, Ryan Stuchbery, Patrick McCoy, Ken Chow, Natalie Kurganovs, Michael Kerger, Anthony Papenfuss, Christopher M Hovens and Niall M Corcoran

–20%, respectively ( 8 , 10 ). The promotion of an obese-like phenotype by androgen deprivation is highly clinically relevant, as obesity (expressed as BMI) is itself associated with the development of prostate cancer, post-prostatectomy biochemical failure and

Open access

Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel and André P van Beek

has been observed ( 36 ). This suggests that the development of hypoglycaemia unawareness cannot be attributed to a specific type of bariatric surgery. The discrepancy between the asymptomatic low blood sugars in our study and the development of