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Luca Giovanella Clinic for Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Clinic for Nuclear Medicine, University Hospital of Zürich, Zürich, Switzerland

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Maria Luisa Garo Mathsly Research, Brescia and Vibo Valentia, Italy

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Domenico Albano Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy

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Rainer Görges Department of Nuclear Medicine, University Hospital of Essen, Essen, Germany

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Luca Ceriani Clinic for Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Faculty of Biomedical Sciences, Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland

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included studies ( n   = 11). Author Year Country Patients Mean age, year % Males (male/female) PTC FTC DTC type prevalence Poorly differentiated or Hurthle or aggressive variant TSH Patients included for Tg-DT Follow

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Laura van Iersel Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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Sarah C Clement Department of Pediatrics, Amsterdam University Medical Center, location VU University Medical Center, Amsterdam, The Netherlands

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Antoinette Y N Schouten-van Meeteren Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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Annemieke M Boot Department of Pediatric Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Hedi L Claahsen-van der Grinten Department of Pediatric Endocrinology, Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands

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Bernd Granzen Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands

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K Sen Han Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands

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Geert O Janssens Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Erna M Michiels Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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W Peter Vandertop Neurosurgical Center Amsterdam, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam and location VU University Medical Center, Amsterdam, The Netherlands

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Dannis G van Vuurden Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Oncology/Hematology, Amsterdam University Medical Center, location VU University Medical Center, Amsterdam, The Netherlands

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Hubert N Caron Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Leontien C M Kremer Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Hanneke M van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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combination with low, normal or mildly elevated thyrotropin (TSH) levels. However, the use of population-based FT4 reference ranges as diagnostic criteria for central hypothyroidism is questionable because the variability of FT4 concentrations within

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Jiayang Lin Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Peizhen Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Yan Huang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Xueyun Wei Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Dan Guo Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Jianfang Liu Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Deying Liu Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Yajuan Deng Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Bingyan Xu Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Chensihan Huang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Xiaoyu Yang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Yan Lu Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China

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Lijing Jia Department of Endocrinology, Shenzhen People’s Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China

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Huijie Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China

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serum thyroid hormone, reduced thyroid stimulating hormone (TSH), and elevated serum TSH receptor antibody (TRAb) levels. All hyperthyroid patients received thionamide treatment. Of them, 46 hyperthyroid patients received thionamide treatment for 3

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Xichang Wang Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Xiaochun Teng Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Chenyan Li Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Yushu Li Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Jing Li Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Weiping Teng Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Zhongyan Shan Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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Yaxin Lai Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

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The non-pregnancy questionnaire covers a total of 35 questions  1 Which of the following indicators do you obtain when diagnosing hyperthyroidism? (Multiple choice) fT3, fT4, tT3, tT4, TSH, thyroid ultrasound, RAIU, thyroid radionuclide scan

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Yukari Maki Department of Pediatric Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Kiyomi Horiuchi Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Takahiro Okamoto Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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randomized controlled trial revealed that restoration of euthyroidism from thyroid-stimulating hormone (TSH) suppression therapy did not affect patient-reported outcomes, as measured by the Multidimensional Fatigue Index-20 ( 15 ). A cross-sectional study

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Kim Magaly Pabst Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Robert Seifert Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

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Nader Hirmas Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Martina Broecker-Preuss Department of Medicine, Ruhr-University Bochum, University Hospital, Knappschaftskrankenhaus Bochum, Bochum, Germany

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Manuel Weber Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Wolfgang Peter Fendler Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Timo Bartel Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Sarah Theurer German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Ken Herrmann Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Rainer Görges Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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an s-Tg measurement (maximum 24 months after last radioiodine ablation) and at least annual follow-ups (including u-hsTg and TSH measurements, as well as ultrasonography). The study was approved by the local ethics committee at the University Hospital

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G Amiyangoda Department of Pharmacology, Faculty of Medicine, University of Peradeniya, Sri Lanka
Diabetes and Endocrine Unit, National Hospital, Kandy, Sri Lanka

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C N Antonypillai Diabetes and Endocrine Unit, National Hospital, Kandy, Sri Lanka

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S S C Gunatilake Diabetes and Endocrine Unit, National Hospital, Kandy, Sri Lanka

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T T Weerathunge Department of Community Medicine, Faculty of Medicine, University of Colombo, Sri Lanka

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D Ediriweera Health Data Science Unit, Faculty of Medicine, University of Kelaniya, Sri Lanka

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S G P D Kosgallana Diabetes and Endocrine Unit, National Hospital, Kandy, Sri Lanka

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R D P Jayawardana Department of Biochemistry, National Hospital, Kandy, Sri Lanka

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H A N D Thissera Department of Biochemistry, National Hospital, Kandy, Sri Lanka

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W J Emalka Faculty of medicine, University of Peradeniya, Sri Lanka

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H U Daraniyagala Faculty of medicine, University of Peradeniya, Sri Lanka

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/or clinical euthyroidism ( 1 , 4 ). The exact prevalence of refractory hypothyroidism is unknown. However, a large retrospective cohort study done in the United Kingdom revealed that about 20–30% had TSH above 4 mIU/L after 5 years of levothyroxine treatment

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Xiaowen Zhang Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Chen Han Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China

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Hongwei Wang State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China

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Xinghong Sun Department of Ophthalmology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Xin Dou Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Xueying He Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Di Wu Department of Radiology, Southeast University Medical School Affiliated Zhongda Hospital, Nanjing, China

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Shanmei Shen Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Dalong Zhu Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Xinlin Zhang Department of Cardiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Yan Bi Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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January 2018 to October 2021. GD was diagnosed based on hyperthyroidism associated with anti-thyrotrophic hormone (TSH) receptor autoantibodies (TRAb). TED was diagnosed by the ophthalmology department based on clinical ophthalmic examinations. TED

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T Grimmichova Institute of Endocrinology, Narodni, Prague, Czech Republic
2nd Department of Internal Medicine, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, Srobarova, Prague, Czech Republic

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M Haluzik Institute of Endocrinology, Narodni, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska, Prague, Czech Republic

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K Vondra Institute of Endocrinology, Narodni, Prague, Czech Republic

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P Matucha Institute of Endocrinology, Narodni, Prague, Czech Republic

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M Hill Institute of Endocrinology, Narodni, Prague, Czech Republic

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hypo- or hyperthyroidism were re-checked for glucose disorders after reaching a euthyroid state. Basal blood samples for the determination of TSH, fT4, fT3, anti-thyroid peroxidase antibodies (anti-TPO), anti-thyroglobulin (anti-Tg), thyrotropin

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Magdalena Lech Faculty of Life Sciences and Medicine, School of Life Course Sciences, King’s College London, London, UK

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Ruvini Ranasinghe Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Royce P Vincent Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
Faculty of Life Sciences and Medicine, School of Life Course Sciences, King’s College London, London, UK

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David R Taylor Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Lea Ghataore Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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James Luxton Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Fannie Lajeunesse-Trempe Department of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK
Quebec Heart and Lung Institute, Laval University, Quebec, Canada

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Pia Roser Department of Endocrinology and Diabetes, University Medical Centre Hamburg Eppendorf, Hamburg, Germany

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Eftychia E Drakou Department of Clinical Oncology, Guy's Cancer Centre - Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK

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Ling Ling Chuah Department of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Ashley B Grossman Green Templeton College, University of Oxford, Oxford, UK
Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, UK
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK

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Simon J B Aylwin Department of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Georgios K Dimitriadis Department of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK
Obesity, Type 2 Diabetes and Immunometabolism Research Group, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Course Sciences, King’s College London, London, UK
Division of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK

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mass ( n  = 25) or pregnant women undergoing endocrine assessment ( n  = 10) in the period between April 2019 and June 2020 were included in the analysis ( Table 1 ). Serum cortisol, full thyroid function tests (TSH, free T4 and free T3

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